Effects of diets enriched with two different plant stanol ester mixtures on plasma ubiquinol-10 and fat-soluble antioxidant concentrations

Metabolism: Clinical and Experimental
Jogchum Plat, Ronald P Mensink

Abstract

Plant stanols lower intestinal cholesterol absorption. This causes a decrease in serum low-density lipoprotein (LDL)-cholesterol, despite a compensatory increase in cholesterol synthesis. We therefore hypothesized that plant stanols also change LDL-cholesterol-standardized concentrations of ubiquinol-10 (a side product of the cholesterol synthesis cascade) and of those fat-soluble antioxidants that are mainly carried by LDL. To examine this, 112 nonhypercholesterolemic subjects consumed low erucic acid rapeseed oil (LEAR)-based margarine and shortening for 4 weeks. For the next 8 weeks, 42 subjects consumed the same products, while the other subjects received products with vegetable oil-based stanols (2.6 g sitostanol plus 1.2 g campestanol daily, n = 36) or wood-based stanols (3.7 g sitostanol plus 0.3 g campestanol daily, n = 34). Consumption of both plant stanol ester mixtures increased cholesterol synthesis and lowered cholesterol absorption, as indicated by increased serum cholesterol-standardized lathosterol and decreased plant sterol concentrations, respectively. Compared with the control group, absolute plasma ubiquinol-10 concentrations were lowered by 12.3% +/- 18.9% (-0.14 microg/mL v. the control group; P =.004; 95%...Continue Reading

Citations

Jun 11, 2002·Annual Review of Nutrition·Richard E Ostlund
Apr 2, 2010·The Journal of Nutrition·Colin D KayPenny M Kris-Etherton
Jan 24, 2015·Journal of Dietary Supplements·Catherine Ulbricht
Nov 18, 2004·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·H A ColganH M Roche
Mar 5, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Sabine BaumgartnerJogchum Plat
Feb 2, 2008·Journal of the American Dietetic Association·Linda Van HornGeeta Sikand
Nov 3, 2004·Journal of Lipid Research·Jogchum PlatRonald P Mensink
Sep 10, 2005·Journal of Lipid Research·Jogchum PlatRonald P Mensink
May 28, 2004·European Journal of Clinical Nutrition·N De JongM C Ocké
Oct 25, 2002·Drugs·Thomas Sudhop, Klaus von Bergmann
Apr 5, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Ornella GuardamagnaFrancesca Abello
Jan 5, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jogchum Plat, Ronald P Mensink
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jogchum Plat, Ronald P Mensink
Feb 15, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Alice H Lichtenstein
Dec 1, 2011·Journal of Clinical Biochemistry and Nutrition·Idris MehmetogluSevil Kurban
Jun 8, 2018·Current Medicinal Chemistry·Francisco Blanco-VacaJosep Julve
Mar 9, 2006·The American Journal of Clinical Nutrition·Elke NaumannRonald P Mensink
Aug 14, 2003·The Journal of Nutritional Biochemistry·Ariënne de JongRonald P Mensink
Jul 5, 2005·The American Journal of Cardiology·Jogchum Plat, Ronald P Mensink
Aug 13, 2003·Mayo Clinic Proceedings·Martijn B KatanUNKNOWN Stresa Workshop Participants

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