Effects of different CYP2C19 genotypes on prognosis of patients complicated with atrial fibrillation taking clopidogrel after PCI

Experimental and Therapeutic Medicine
Qifeng ZhangJunping Huang

Abstract

The effects of different cytochrome P450 2C19 (CYP2C19) genotypes on the prognosis of clopidogrel resistance in patients complicated with atrial fibrillation taking clopidogrel after percutaneous coronary intervention (PCI) were investigated. Eighty patients who were complicated with atrial fibrillation and treated with clopidogrel antiplatelet therapy after PCI in Meizhou Hospital Affiliated to Zhongshan University from September 2015 to January 2017 were selected, and divided into two groups according to the CYP2C19 genotype: extensive metabolism (EM) group and poor metabolism (PM) group. The related risk factors of clopidogrel resistance were determined, and the platelet aggregation rate and clopidogrel resistance rate were compared between the two groups during treatment. Non-fatal myocardial infarction and serious life-threatening complications in the two groups were observed. The increased total cholesterol level and the history of smoking and drinking were the independent risk factors of atrial fibrillation after PCI. The platelet aggregation rates in the EM group at 1, 3 and 12 months after medication were significantly lower than those in the PM group in the same period (P<0.05). The clopidogrel resistance rates in EM ...Continue Reading

References

Mar 28, 2017·Pharmacogenomics·Larisa H CavallariJulie A Johnson
Jun 4, 2017·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Francesca RosafioAndrea Zini
Jun 10, 2017·International Journal of Clinical Pharmacy·Jing LiHuPing Wang
Jun 13, 2017·Pharmacogenomics·Vacis TatarunasVaiva Lesauskaite
Aug 3, 2017·International Journal of Clinical Pharmacology and Therapeutics·Jinbiao ZhangZhenguang Li
Aug 10, 2017·Expert Opinion on Drug Metabolism & Toxicology·Elliot Berinstein, Andrew Levy
Aug 16, 2017·Journal of Community Hospital Internal Medicine Perspectives·Seyed Abbas MirabbasiGang Cheng
Sep 13, 2017·Journal of Vascular Surgery·Mina GuirgisShirley Jansen
Sep 16, 2017·European Journal of Clinical Pharmacology·Dorota DanielakFranciszek Główka

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Citations

Jul 2, 2020·Journal of Clinical Medicine·Wilbert Bor, Diana A Gorog

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

Statistical Product and Service Solutions ( SPSS )

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