PMID: 2492336Jan 1, 1989Paper

Effects of different degrees of iron deficiency on cytochrome P450 complex and pentose phosphate pathway dehydrogenases in the rat

The Journal of Nutrition
A DhurS Hercberg

Abstract

Four groups of weanling male rats were fed one of three iron-deficient diets (6, 18 and 23 mg iron/kg diet) or a normal iron-containing diet (41 mg iron/kg diet) for 30 d. The effects of the diets on various iron status parameters were determined and four enzymes were assayed: cytochrome P450 (P450) and NADPH cytochrome P450 reductase (P450-RED) in liver and intestine microsomes, and glucose-6-phosphate dehydrogenase (G6P-DH) and 6-phosphogluconate dehydrogenase (6PG-DH) in liver, intestine and erythrocyte cytosol. Rats fed 6 mg iron/kg diet were severely anemic, whereas rats fed 18 or 23 mg iron/kg diet were moderately or mildly iron-deficient, as shown by their hemoglobin levels, hematocrit, red blood cell parameters, erythrocyte protoporphyrin and liver iron stores. P450 concentration and P450-RED activity in liver were unaffected by iron deficiency, but P450 concentration was markedly lower in the intestine of the three iron-deficient groups than in the controls. Activities of G6P-DH and 6PG-DH were not impaired in liver or intestine, except that liver 6PG-DH activity of severely anemic rats was less than that of control rats. However, severe and moderate iron deprivation resulted in a stimulation of G6P-DH and 6PG-DH activ...Continue Reading

Citations

Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·S Hercberg, P Galan
Apr 13, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C Ioannides
Oct 20, 2009·Nutrition and Cancer·Daniel PráMichael Fenech
Nov 30, 2016·ELife·Samira Lakhal-LittletonPeter A Robbins
Aug 5, 2017·Journal of Applied Physiology·Samira Lakhal-Littleton, Peter Alistair Robbins
Oct 21, 2017·Current Medical Research and Opinion·Khaled M Musallam, Ali T Taher
Jan 1, 1991·Critical Reviews in Toxicology·L S Kaminsky, M J Fasco
Aug 31, 2019·Pharmaceuticals·Samira Lakhal-Littleton
Sep 27, 2013·The Journal of Toxicological Sciences·Mariko TomitaTakanori Harada
Jul 28, 2020·The Journal of Reproduction and Development·Shingo TonaiYasuhisa Yamashita
Mar 30, 2021·Frontiers in Immunology·Aysegül AksanJürgen Stein
Jan 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·N J Rao, V Jagadeesan
Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·A DhurS Hercberg
Aug 7, 2010·Nutrition·Daniel PráSilvia Isabel Rech Franke
Sep 10, 2011·Journal of the American College of Cardiology·Darlington O OkonkoPhilip A Poole-Wilson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.