Abstract
There is a lack of research on the effect of low dose of angiotensin receptor blockers combined with spironolactone, and the effect of high dose of angiotensin receptor blockers alone on the urinary albumin excretion rate (UAER) in elderly patients with early type 2 diabetic nephropathy (DN). We conducted a prospective, randomized, open-label, parallel-controlled study that included 244 elderly patients with early DN and mild-to-moderate essential hypertension. Patients were randomly divided into 4 groups: low-dose irbesartan (group A), high-dose irbesartan (group B), low-dose irbesartan combined with spironolactone (group C) and high-dose irbesartan combined with spironolactone (group D). Changes in UAER, serum potassium and blood pressure were compared. There were no statistical differences in the baseline characteristics among groups. Furthermore, no significant difference in blood pressure before and after treatment was found among different groups. After 72-week treatment, UAER in group D was lower compared to group A and B (P < 0.05). Meanwhile, compared with group B, UAER in group C decreased significantly (P < 0.05). Additionally, significantly higher serum potassium was found in group D compared to other groups (P < 0....Continue Reading
References
Sep 22, 2001·The New England Journal of Medicine·E J LewisUNKNOWN Collaborative Study Group
Sep 22, 2001·The New England Journal of Medicine·H H ParvingUNKNOWN Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group
Nov 20, 2004·Diabetologia·K J SchjoedtH-H Parving
Aug 27, 2005·Diabetes Care·Kasper RossingHans-Henrik Parving
Dec 13, 2005·Journal of Clinical Pharmacy and Therapeutics·M SaitoY Yasumura
Oct 21, 2006·Journal of Hypertension·Anton H van den MeirackerFrans Boomsma
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Nov 21, 2009·Journal of the American Society of Nephrology : JASN·Uzma F MehdiRobert D Toto
Jul 23, 2011·Clinical and Experimental Hypertension : CHE·Tomohiro HanazawaYutaka Imai
Sep 7, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alireza EsteghamatiManouchehr Nakhjavani
Nov 5, 2013·Cardiovascular Diabetology·Yayoi NishidaSatoshi Asai
Dec 10, 2013·European Journal of Internal Medicine·Thomas A MavrakanasPierre-Yves Martin
Nov 18, 2014·Clinical Endocrinology·Peng LiuYangang Wang
Mar 22, 2015·Clinical and Experimental Nephrology·Sawako KatoSeiichi Matsuo
Sep 15, 2015·Current Medical Research and Opinion·Peng LiuYangang Wang
Nov 17, 2015·Therapeutic Advances in Chronic Disease·Marissa L WolffJamie N Brown
Nov 22, 2015·Diabetes/metabolism Research and Reviews·Yu-Hung ChangYau-Jiunn Lee
Citations
Aug 30, 2019·International Journal of Clinical Practice·Chao Zuo, Gaosi Xu
Oct 11, 2019·Current Opinion in Nephrology and Hypertension·Marie Frimodt-MøllerPeter Rossing
Oct 28, 2020·The Cochrane Database of Systematic Reviews·Edmund Ym ChungGiovanni Fm Strippoli
Dec 3, 2020·Current Medical Science·Ling-Na FangLi Zhang
Dec 11, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xiaotong WangNanfang Li
Sep 4, 2021·Medicine·Mingming ZhaoYu Zhang