Effects of different exposures of hyperbaric oxygen on ligament healing in rats

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Yoshimasa IshiiYutaka Miyanaga

Abstract

Hyperbaric oxygen (HBO) is a method of augmenting, intermittently, oxygen availability to tissues. We examined the effect of three different HBO exposures on the healing of experimentally induced ligament lacerations in the right hind limb of 44 male Wistar rats. Animals were divided into four groups after ligament injury: (a) control group, animals breathed room air at 1 ATA (atmosphere absolute) in a hyperbaric chamber for 60 min; (b) HBO treatment at 1.5 ATA for 30 min once a day, (c) HBO treatment at 2 ATA for 30 min once a day, (d) 2 ATA for 60 min once a day. At 14 days post-ligament injury, we compared the ligaments of the four treatment groups for gross appearance, histology and expression of pro-alpha(I) mRNA by northern hybridization. Our results indicate that HBO was effective in promoting ligament healing compared to control (p < 0.01). Of these three exposures, HBO at 2 ATA for 60 min was the most effective, resulting in enhanced extra-cellular matrix deposition as measured by collagen synthesis.

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Citations

Aug 5, 2008·European Journal of Applied Physiology·Keitaro KuboHiroaki Kanehisa
Mar 31, 2005·Biochemical and Biophysical Research Communications·Jochen G HofstaetterMelvin J Glimcher
Jul 26, 2003·International Journal of Pediatric Otorhinolaryngology·Nadan M PetriHrvoje Stipancević
Oct 14, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yoshimasa IshiiYutaka Miyanaga
Jun 15, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ahmad Y SheikhThomas K Hunt
Apr 1, 2011·Therapeutic Advances in Musculoskeletal Disease·Pedro BarataFrankim Marques
Jul 28, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chi-Chien NiuWen-Jer Chen
Aug 14, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chi-Chien NiuWen-Jer Chen
Jun 9, 2004·International Journal of Pediatric Otorhinolaryngology·Atakan AydinBilge Bilgic
Aug 12, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Li-Jen YuanPaul Y Lin
Jul 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ashley L FarrisWarren L Grayson
Oct 3, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hossam B El-ZawawyLinda J Sandell
Sep 6, 2005·Sports Medicine·Yoshimasa IshiiMitsuo Ochi
Dec 27, 2019·Medicine and Science in Sports and Exercise·Navid MoghadamRenie Guilliod
Aug 3, 2020·Plastic and Reconstructive Surgery·Yuriko YoshinoyaBong-Sung Kim
Jul 3, 2004·Clinical Orthopaedics and Related Research·Hirotaka MashitoriKoichi Saotome
Dec 8, 2004·The Journal of Trauma·Robert Wen-Wei HsuKam-Fai Lee

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