PMID: 11913407Mar 27, 2002Paper

Effects of different hormone replacement regimens on postmenopausal women with abnormal lipid levels. Menopause Study Group

Climacteric : the Journal of the International Menopause Society
J H PickarR A Lobo

Abstract

A retrospective, subset analysis of the prospective Menopause Study Group data was performed to determine the effects of four conjugated estrogens (CE) + medroxyprogesterone acetate (MPA) regimens and one unopposed CE regimen on the lipid profiles of women with abnormal lipid levels (n = 525). Previously unpublished data on the entire study population were also reviewed to determine the effects of these hormone replacement regimens on blood pressure and weight (n = 1368, 1374, respectively). During a 1-year, prospective trial, all patients took CE. Groups A and B also took continuous MPA 2.5 and 5 mg, respectively, C and D took MPA 5 and 10 mg for the last 14 cycle days of each 28-day cycle, and E took matching placebo tablets to replace MPA. After 1 year, all five regimens were directly associated with significant elevations in high density lipoprotein-2 (HDL2) cholesterol and significant reductions in low density lipoprotein (LDL) cholesterol (p < 0.05), although unopposed estrogen produced the greatest increase in HDL2 cholesterol. The CE + MPA regimens were also associated with significant decreases in total cholesterol. Triglyceride levels did not change significantly from baseline in any treatment group (baseline values >...Continue Reading

References

Oct 1, 1992·British Journal of Obstetrics and Gynaecology·M FalkebornT Naessén
Sep 12, 1991·The New England Journal of Medicine·M J StampferC H Hennekens
Jan 1, 1991·Archives of Internal Medicine·B E HendersonR K Ross
Apr 10, 1991·JAMA : the Journal of the American Medical Association·E Barrett-Connor, T L Bush
Dec 1, 1990·British Journal of Obstetrics and Gynaecology·K HuntK McPherson
Jan 1, 1990·Annals of the New York Academy of Sciences·R A Lobo
Dec 1, 1990·Archives of Internal Medicine·J M SullivanD M Mirvis
Aug 1, 1988·American Journal of Obstetrics and Gynecology·B E HendersonR K Ross
Jun 1, 1986·American Journal of Obstetrics and Gynecology·B E HendersonT M Mack
Apr 14, 1994·The New England Journal of Medicine·P E Belchetz
Jan 1, 1993·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·W M Hern
Apr 29, 1993·The New England Journal of Medicine·M H CriquiC E Davis
May 1, 1993·The Clinical Investigator·M RiedelP Lichtlen

❮ Previous
Next ❯

Citations

May 28, 2008·Gender Medicine·Sharon Silbiger, Joel Neugarten
Mar 5, 2003·Advances in Renal Replacement Therapy·Sharon R Silbiger, Joel Neugarten

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.