Effects of different liquid diets and sustained ethanol release on alcohol metabolism

Alcohol
C K EricksonR L Shorey

Abstract

The effects of two liquid diets, Sustacal and Shorey-AIN, on liver alcohol dehydrogenase (ADH) activity and ethanol clearance were tested in rats under conditions of high ethanol exposure for nine days. High blood ethanol levels (BEL) were produced through a combination of an initial intubated dose of ethanol sustained ethanol release tube (SERT), and ethanol as 37% of total energy in the liquid diet. Under free-feeding conditions, rats consumed slightly more ethanol per unit body weight in the Shorey-AIN diet, a diet formulated for rodent nutrition, than in the Sustacal diet, a diet originally intended for human consumption. However, BEL were significantly higher in the Sustacal group than in the Shorey-AIN group. No differences in ethanol clearance rates were observed between the groups. On the other hand, total liver ADH activity was significantly reduced in both the Shorey AIN/ethanol and the Sustacal/ethanol groups, compared to lab chow controls. When the Sustacal diet was fortified with casein and methionine so that the protein content matched that of the Shorey AIN diet, the BEL were no longer significantly higher than those produced by the Shorey AIN/ethanol diet. The results demonstrate the effect of nutritional factor...Continue Reading

References

Mar 1, 1979·Journal of the American Oil Chemists' Society·L D SatterleeJ M Tennyson
Jan 1, 1977·Addictive Behaviors·T B BakerC A Atkinson
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Apr 1, 1980·Pharmacology, Biochemistry, and Behavior·M E GoldmanC K Erickson
Dec 1, 1980·Pharmacology, Biochemistry, and Behavior·C K EricksonJ W McGinity

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