Effects of different macromolecular models on reproducibility of FID-MRSI at 7T.

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Eva HeckovaWolfgang Bogner

Abstract

A properly characterized macromolecular (MM) contribution is essential for accurate metabolite quantification in FID-MRSI. MM information can be included into the fitting model as a single component or parameterized and included over several individual MM resonances, which adds flexibility when pathologic changes are present but is prone to potential overfitting. This study investigates the effects of different MM models on MRSI reproducibility. Clinically feasible, high-resolution FID-MRSI data were collected in ~5 min at 7 Tesla from 10 healthy volunteers and quantified via LCModel (version 6.3) with 3 basis sets, each with a different approach for how the MM signal was handled: averaged measured whole spectrum (full MM), 9 parameterized components (param MM) with soft constraints to avoid overparameterization, or without any MM information included in the fitting prior knowledge. The test-retest reproducibility of MRSI scans was assessed voxel-wise using metabolite coefficients of variation and intraclass correlation coefficients and compared between the basis sets. Correlations of concentration estimates were investigated for the param MM fitting model. The full MM model provided the most reproducible quantification of tota...Continue Reading

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Citations

Apr 2, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Stanislav MotykaWolfgang Bogner
Nov 14, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Philipp MoserWolfgang Bogner
May 14, 2020·NMR in Biomedicine·Wolfgang BognerAnke Henning
May 21, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karl LandheerChristoph Juchem
Aug 31, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Saipavitra Murali-ManoharAnke Henning
Jul 17, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dunja SimicicCristina Cudalbu

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Methods Mentioned

BETA
NMR

Software Mentioned

MatLab
semi
LASER
NMR Scope ( jMRUI
MathWorks
FSL
MINC
MUSICAL
Bash
STEAM

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