Effects of different principles of Traditional Chinese Medicine treatment on TLR7/NF-κB signaling pathway in influenza virus infected mice

Chinese Medicine
Ying-Jie FuZhen-You Jiang

Abstract

Influenza virus is a single-stranded RNA virus that causes influenza in humans and animals. About 600 million people around the world suffer from influenza every year. Upon recognizing viral RNA molecules, TLR7 (Toll-like receptor) initiates corresponding immune responses. Traditional Chinese Medicines (TCMs), including Yinqiao powder, Xinjiaxiangruyin and Guizhi-and-Mahuang decoction, have been extensively applied in clinical treatment of influenza. Although the therapeutic efficacy of TCMs against influenza virus in vivo was reported previously, its underlying mechanisms are not clearly understood. This study aimed to investigate the immunological mechanisms in the treatment of influenza virus infected mice with three Chinese herbal compounds as well as the effect on TLR7/NF-κB signaling pathway during recovery. Wild type and TLR7 KO C57BL/6 mice were infected with influenza virus FM1 and then treated with three TCMs. The physical parameters of mice (body weight and lung index) and the expression levels of components in TLR7/NF-κB signaling pathway were evaluated. After viral infection, Guizhi-and-Mahuang decoction and Yinqiao powder showed better anti-viral effect under normal condition. Compared to the viral control group, ...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jongdae LeeHoward B Cottam
Jan 31, 2004·Seminars in Immunology·Kiyoshi Takeda, Shizuo Akira
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Mar 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer M LundRichard A Flavell
Sep 30, 2004·Nature Immunology·Akiko Iwasaki, Ruslan Medzhitov
Sep 30, 2005·The New England Journal of Medicine·Anne Moscona
Dec 7, 2007·Seminars in Immunology·Ivaylo I IvanovDan R Littman
Jan 13, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Iain StephensonMaria Zambon
Mar 28, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory A PolandInna G Ovsyannikova
Oct 14, 2009·JAMA : the Journal of the American Medical Association·Anand KumarUNKNOWN Canadian Critical Care Trials Group H1N1 Collaborative
Feb 19, 2010·Mucosal Immunology·A RayP Ray
Mar 30, 2010·Immunity·Amanda L Blasius, Bruce Beutler
May 13, 2010·The American Journal of the Medical Sciences·YuanYuan DingSiwang Wang
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Keng-Hsin LanShou-Dong Lee
Mar 20, 2012·Cancer Management and Research·Anton G Kutikhin, Arseniy E Yuzhalin
Jun 26, 2012·Respiratory Research·Lennart GreiffHenrik Widegren
Aug 29, 2012·Journal of Asian Natural Products Research·Chen ChenXiao-Yin Chen
Mar 7, 2013·Nature Communications·Anne WalterMaries van den Broek
Jan 1, 2013·Annual Review of Animal Biosciences·Makoto Ozawa, Yoshihiro Kawaoka
Jun 22, 2016·Archives of Pharmacal Research·Xin-Yan QuSheng-Qi Wang
Dec 28, 2016·International Journal of Molecular Sciences·Aitor Nogales, Luis Martínez-Sobrido

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Citations

Jul 18, 2020·Medicinal Research Reviews·Zhi-Jun ZhangRong-Tao Li
Nov 24, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao ZhengZhenyou Jiang
Mar 15, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yanbo WangKe Zen
Dec 22, 2020·International Immunopharmacology·Ashkan BagheriManica Negahdaripour
Feb 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hang YinSong Wang
Jul 27, 2021·Annals of Microbiology·Trishala GopikrishnaElavarashi Elangovan
Aug 25, 2020·Acta Pharmaceutica Sinica. B·Yanfang XianHongxi Xu

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Methods Mentioned

BETA
Flow cytometry

Software Mentioned

Flowjo7
SPSS
ImageJ

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