Effects of different ratios of monounsaturated and polyunsaturated fatty acids to saturated fatty acids on regulating body fat deposition in hamsters

Fang-Hsuean LiaoYi-Wen Chien


Effects of monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid consumption on regulating body fat accumulation and body weight gain are controversial between animal and human studies. We designed a 2 x 2 factorial study, with two levels of MUFAs (60% and 30%) and two levels of polyunsaturated-to-saturated fatty acid (P/S) ratio (5 and 3) to prepare four kinds of experimental oils consisting of 60% MUFAs with a high or low P/S ratio (HMHR or HMLR, respectively) or 30% MUFAs with a high or low P/S ratio (LMHR or LMLR, respectively). Thirty-two male golden Syrian hamsters were randomly divided into four groups and fed the experimental diets containing 15% (w/w) fat for 12 wk. No difference was observed in the mean daily food intake. Hamsters fed the LMLR diet had increased weight gain, epididymal and retroperitoneal white adipose tissues, plasma non-esterified fatty acids, insulin, hepatic acetyl coenzyme A carboxylase and malic enzyme activities, and mRNA expressions of peroxisome proliferator-activated receptor-alpha and sterol regulatory element-binding protein-1c among all groups (P < 0.05). Hamsters fed the HMHR diet had lower plasma insulin levels and hepatic acetyl coenzyme A carboxylase activities among groups...Continue Reading

Associated Clinical Trials


Apr 1, 1992·Metabolism: Clinical and Experimental·P J JonesC L Birmingham
Nov 1, 1985·The American Journal of Clinical Nutrition·P J JonesM T Clandinin
Apr 1, 1985·The Biochemical Journal·G M SmallM J Connock
Dec 1, 1972·Analytical Biochemistry·L L BieberT Helmrath
Oct 1, 1982·Physiology & Behavior·G N Wade
Apr 1, 1994·Journal of Nutritional Science and Vitaminology·Y F Lu, H L Wu
Dec 1, 1996·Metabolism: Clinical and Experimental·S IkemotoO Ezaki
May 23, 1998·The International Journal of Biochemistry & Cell Biology·A PalouP Oliver
Dec 10, 1998·The American Journal of Clinical Nutrition·G A Bray, B M Popkin
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·I ShimomuraJ L Goldstein
Aug 10, 2000·The Journal of Biological Chemistry·E DuplusC Forest
Jan 30, 2002·The American Journal of Clinical Nutrition·Víctor M RodríguezAndreu Palou
Mar 18, 2003·Journal of Lipid Research·F Jeffrey FieldSatya N Mathur
Dec 4, 2003·The British Journal of Nutrition·F SoriguerS Morcillo
Jun 14, 2005·Biochimica Et Biophysica Acta·Lise MadsenKarsten Kristiansen
Sep 6, 2005·The Journal of Nutrition·Maria Luz Fernandez, Kristy L West
Oct 8, 2005·The American Journal of Clinical Nutrition·Tomoo OkadaKensuke Harada
Oct 28, 2005·The Journal of Nutrition·Donald B JumpOlivier Demeure
May 23, 2006·Lipids·M Bes-RastrolloM A Martínez-González
May 25, 2006·Journal of Molecular Endocrinology·R BuettnerL C Bollheimer
Sep 12, 2006·The Journal of Nutritional Biochemistry·Helmut Schröder
Dec 7, 2006·Annals of the New York Academy of Sciences·W P T JamesR Leach
Aug 25, 2007·Pflügers Archiv : European journal of physiology·Allain Amador BuenoCláudia Maria Oller do Nascimento
Aug 30, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·J P H Wilding
Jan 8, 2008·Progress in Lipid Research·Koji Nagao, Teruyoshi Yanagita

❮ Previous
Next ❯


Feb 26, 2011·The Proceedings of the Nutrition Society·S C CottinW L Hall
Jul 16, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Jasmine BhathenaSatya Prakash
Feb 22, 2014·The British Journal of Nutrition·Elaine PattersonCatherine Stanton
Oct 8, 2016·Food & Function·Jailane de Souza AquinoTânia Lúcia Montenegro Stamford
Jan 30, 2021·Food Research International·Orquídea Vasconcelos SantosBarbara Elisabeth Teixeira-Costa

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.