PMID: 15387976Sep 25, 2004Paper

Effects of different triple therapies on duodenal ulcer-associated Helicobacter pylori infection and a one-year follow-up study

Zhonghua yi xue za zhi
Multiple Center Study Group In Beijing Area, China

Abstract

To evaluate the effects of different triple therapies on healing of duodenal ulcer associated with Helicobacter pylori (Hp) infection; Hp eradication; and ulcer recurrence. 248 patients with Hp-associated active duodenal ulcer confirmed by endoscopy, 193 males and 55 females, were randomized to receive OAC(250): omeprazole (0.20 mg bid) + amoxicillin (1000 mg bid) + clarithromycin (250 mg bid), for 1 week (group A1) or 2 weeks (group A2); OAC(500): omeprazole (0.20 mg bid) + amoxicillin (1000 mg bid) + clarithromycin (500 mg bid), for 1 week (group B1) or 2 weeks (group B2); or OAM: omeprazole (0.20 mg bid) + amoxicillin (1000 mg bid) + metronidazole (400 mg bid), for 1 week (group C1) or 2 weeks (group C2) respectively. Endoscopy and biopsy were performed at least 4 weeks after the end of therapy to unde5rgo histological examination. Rapid urease test was performed. Endoscopy and histological examination and rapid urease test were performed twice again on the patients with the ulcer healed 6 months and one year after so as to observe the recurrence rate. By protocol analysis the ulcer healing rates of the groups A1, A2, B1, B2, C1, and C2 were 93.3% (42/45), 92.7% (38/41); 89.2% (33/37), 94.9% (37/39); 88.4% (38/43), and 93.0%...Continue Reading

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