Effects of different tuberculin skin-testing regimens on gamma interferon and antibody responses in cattle experimentally infected with Mycobacterium bovis

Clinical and Vaccine Immunology : CVI
M V PalmerK P Lyashchenko

Abstract

Although tuberculin skin testing has been a hallmark of bovine tuberculosis eradication campaigns, it lacks sensitivity, can be confounded by exposure to nontuberculous mycobacteria, and cannot be repeated for 60 days due to desensitization. To overcome these difficulties, an effective whole-blood cellular immunoassay for bovine gamma interferon (IFN-gamma) has been developed. The IFN-gamma test is commonly used in conjunction with tuberculin skin testing as a confirmatory test following a positive response to the caudal fold test (CFT). The present study was conducted to determine the effect of different tuberculin skin-testing regimens on IFN-gamma and antibody production by using calves that were experimentally infected with Mycobacterium bovis. Holstein calves were CFT tested 60 days after inoculation and the comparative cervical test (CCT) was conducted 7 (7-day CCT) or 55 (55-day CCT) days after the CFT. In both the 7-day CCT and 55-day CCT groups, IFN-gamma responses increased 3 days after the CFT; this was immediately followed by a decrease to pre-skin test levels 7 days after the CFT. In both groups, the application of the CCT at 7 or 55 days after the CFT resulted in no significant increase in IFN-gamma production. Th...Continue Reading

References

Jul 1, 1977·Australian Veterinary Journal·A W LepperC W Pearson
Jul 1, 1978·Journal of Biological Standardization·R D Angus
Jun 1, 1992·Veterinary Microbiology·J HannaJ J O'Brien
Nov 1, 1988·Journal of Comparative Pathology·D G Pritchard
Jun 1, 1985·Australian Veterinary Journal·B L Radunz, A W Lepper
Jul 1, 1995·Scandinavian Journal of Immunology·M HarboeS Haga
May 1, 1994·Veterinary Microbiology·P R Wood, J S Rothel
Mar 1, 1994·Scandinavian Journal of Immunology·T FifisP R Wood
Sep 15, 2000·Journal of Immunological Methods·K P LyashchenkoM L Gennaro
Apr 6, 2001·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·D L WhippleS L Jones
Jul 21, 2001·Tuberculosis·P R Wood, S L Jones

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Citations

May 9, 2009·PloS One·Meetu SethSrinand Sreevatsan
Sep 15, 2009·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Tim BoutsAndrew Routh
Mar 22, 2014·Journal of the American Veterinary Medical Association·Tolani I FranciscoNancy J Roberts
Jun 22, 2012·Veterinary Medicine International·Ashutosh WadhwaShigetoshi Eda
Apr 29, 2014·Research in Veterinary Science·Javier BezosLucas Domínguez
Apr 17, 2010·Veterinary Immunology and Immunopathology·Sven D C ParsonsPaul D van Helden
Mar 12, 2010·Veterinary Immunology and Immunopathology·Irene SchillerBruno Oesch
Jul 14, 2007·Veterinary Immunology and Immunopathology·Tyler C ThackerW Ray Waters
Feb 9, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Geoffrey W de LisleBryce M Buddle
Apr 27, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Judith R StabelSuelee Robbe-Austerman
Sep 27, 2019·The Veterinary Record·Catalina Picasso-RissoJulio Alvarez
Jun 9, 2006·Clinical and Vaccine Immunology : CVI·W R WatersK P Lyashchenko
Jul 10, 2009·Clinical and Vaccine Immunology : CVI·Irene SchillerBruno Oesch
Aug 9, 2020·Transboundary and Emerging Diseases·Catalina Picasso-RissoAndres Perez
Jul 23, 2019·Science Advances·Sreenidhi SrinivasanVivek Kapur
Aug 29, 2019·Frontiers in Veterinary Science·Catalina Picasso-RissoJulio Alvarez
Nov 8, 2017·Frontiers in Veterinary Science·Aideen E KennedyRiona G Sayers
Feb 13, 2020·Veterinary Immunology and Immunopathology·Konstantin P LyashchenkoW Ray Waters

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