PMID: 696639Oct 1, 1978Paper

Effects of digitalis on atrial vulnerability

The American Journal of Cardiology
T R Engel, A D Gonzalez

Abstract

The effects of digitalis on vulnerability to atrial fibrillation and flutter were assessed in man, using the model of repetitive atrial firing initiated by post-drive atrial extrastimulation. Nine patients without heart failure or significant mitral valve disease were tested before and 30 minutes after the administration of 0.01 mg/kg ouabain. When repetitive firing was manifested by flutter, neither the flutter cycle length nor the interval from the initiating beat to the first flutter beat was consistently altered by ouabain. Repetitive firing was found at the atrial site with the shortest functional refractory period. The vulnerable zone bordered this refractory period. The functional refractory period was lengthened after ouabain, from 231 +/- 13 to 246 +/- 15 msec (mean +/- standard error of the mean) (P less than 0.025). Partly because of prolonged refractoriness, the vulnerable zone was curtailed by ouabain, from 32.2 +/- 5.7 to 9.4 +/- 4.6 msec (P less than 0.001). This result suggests a protective effect of digitalis against atrial fibrillation and flutter independent of its hemodynamic actions.

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Citations

Jun 15, 1983·Klinische Wochenschrift·T PopW Kasper
May 1, 1991·Journal of the American College of Cardiology·P Della BellaH J Wellens
Mar 1, 1983·Journal of the American College of Cardiology·T R Engel, J C Luck
Jul 1, 1985·Journal of the American College of Cardiology·R L GoldA M Ross
Mar 1, 1979·Pacing and Clinical Electrophysiology : PACE·T R EngelA D Gonzalez
Jul 1, 1996·Pacing and Clinical Electrophysiology : PACE·H OdakuraA Ishida
Oct 30, 1998·Pacing and Clinical Electrophysiology : PACE·M ZimmermannJ Metzger
May 1, 1985·The American Journal of Cardiology·A S PickoffH Gelband
Jun 4, 1992·The American Journal of Cardiology·B H Sarter, F E Marchlinski
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Feb 15, 1990·The American Journal of Cardiology·H D GössingerH Mösslacher
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Mar 1, 1986·Pacing and Clinical Electrophysiology : PACE·P R Kowey, T D Friehling
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Sep 15, 1996·Circulation·H S FriedmanA Bharadwaj
Jul 1, 1982·Pacing and Clinical Electrophysiology : PACE·T R Engel
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