PMID: 43072Oct 1, 1979

Effects of digoxin on isolated human peripheral arteries and veins

Acta Pharmacologica Et Toxicologica
E MikkelsenO L Pedersen

Abstract

In isolated human crural arteries and veins, digoxin induced slowly developing, long-lasting contractions. These contractions were not diminished by alpha-adrenoceptor blockade or by washing, but were abolished by the calcium antagonist nifedipine. In the presence of digoxin, the maximum contractile responses to noradrenaline (18 microM) and potassium (127 mM) markedly increased, and the glycoside shifted the noradrenaline concentration-response curve to the left. Immersion of vein preparations in calcium-free medium for 30 min. abolished the digoxin contraction, whereas responses could still be elicited by potassium and noradrenaline. A change of the extracellular potassium concentration from 4.6 to 6.9 and 9.2 mM caused relaxation, and a further increase to 13.8 mM contracted the preparations. After pretreatment with digoxin (1 micronM), a potassium change from 4.6 to 1.15 mM caused relaxation and all concentrations exceeding 4.6 mM produced contraction. It is concluded that digoxin has a direct contractile effect on isolated human crural vessels, and that this effect is dependent on the extracellular calcium concentration. In the presence of the glycoside, the responses to noradrenaline and potassium are potentiated. Vascula...Continue Reading

References

Dec 1, 1984·British Journal of Clinical Pharmacology·P B HansenE Steiness
Jan 1, 1981·Acta Medica Scandinavica. Supplementum·K E Andersson
Nov 1, 1992·Hypertension·L Rodríguez-MañasJ Marín
Jun 26, 2001·Clinical and Experimental Pharmacology & Physiology·B A NairD D Gutterman
Oct 1, 1992·Circulation Research·C F Sánchez-FerrerJ Marín
May 31, 2001·Clinical and Experimental Pharmacology & Physiology·B V MühlenL Lind

Citations

Dec 1, 1977·The Journal of Clinical Investigation·K B SagarW J Powell
Dec 1, 1977·Japanese Journal of Pharmacology·H NakajimaM Hoshiyama
Jan 1, 1978·Circulation Research·P A Murray, H V Sparks
May 15, 1978·Klinische Wochenschrift·T BrechtE Schäfer
Jul 1, 1978·Acta Pharmacologica Et Toxicologica·E SteinessH Ring-Larsen
Oct 1, 1978·Acta Pharmacologica Et Toxicologica·E MikkelsenO L Pedersen
Oct 17, 1973·Pflügers Archiv : European journal of physiology·G Biamino, H J Wessel
Jan 1, 1974·The Journal of Clinical Investigation·N P HamlinW J Powell
Jan 1, 1968·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·P KonoldK Brecht
Jun 1, 1960·The Journal of Clinical Investigation·J ROSSE BRAUNWALD

Related Concepts

Muscle, Smooth, Vascular
Calcium
Potassium
Muscle Relaxation Phase
Norepinephrine, (+, -)-Isomer
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Mapluxin
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Drug Augmentation

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