Effects of dihydralazine on renal water and aquaporin-2 excretion in humans

Scandinavian Journal of Clinical and Laboratory Investigation
Henrik VaseErling B Pedersen

Abstract

Dihydralazine is a vasodilator that lowers blood pressure, but often also leads to significant water and sodium retention. To characterize the effect of dihydralazine on renal sodium and water handling, we tested the hypothesis that dihydralazine causes water retention parallel with an increase in urinary excretion of aquaporin-2 (u-AQP2) in healthy humans. The effect of intravenous infusion of dihydralazine in three doses (3.125 mg, 6.250 mg and 9.375 mg) on urinary AQP2, water and sodium excretion, heart rate (HR), blood pressure (BP) and vasoactive hormones was measured in a randomized, placebo-controlled, double-blind, crossover study in 17 healthy subjects. Glomerular filtration rate (GFR) and renal tubular function were determined with the continuous infusion clearance technique and vasoactive hormones with radioimmunoassays. Dihydralazine compared to placebo had no impact of u-AQP2 (effect of dihydralazine versus placebo +/-SE) (-0.074+/-0.048 ng/min versus -0.015+/-0.034 ng/min; p = 0.42), despite significant reductions in urine output and free water clearance after 9.375 mg of dihydralazine. Dihydralazine significantly lowered BP and increased HR, plasma levels of angiotensin II and (except after 3.125 mg) atrial natri...Continue Reading

References

Dec 1, 1976·Clinical Science and Molecular Medicine. Supplement·R C TaraziA P Niarchos
Nov 1, 1985·Journal of Cardiovascular Pharmacology·G G BelzB Schneider
Sep 1, 1989·Journal of Applied Physiology·M WehlingR Gerzer
Jul 1, 1989·Kidney International·H A KoomansE J Dorhout Mees
Jul 15, 1999·Journal of the American Society of Nephrology : JASN·H WenS Nielsen
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G F DiBona
Apr 9, 2001·American Journal of Physiology. Renal Physiology·R S PedersenE B Pedersen
Jan 5, 2002·Physiological Reviews·Søren NielsenMark A Knepper
Oct 16, 2002·Current Cardiology Reports·Franz H Messerli
Dec 9, 2004·American Journal of Physiology. Renal Physiology·Tae-Hwan KwonSøren Nielsen
Jul 5, 2005·Cardiovascular Research·John R Dietz
Sep 22, 2005·American Journal of Physiology. Renal Physiology·Weidong WangSøren Nielsen
Apr 26, 2006·Nephron. Physiology·JongUn LeeKi Chul Choi
Aug 10, 2006·American Journal of Physiology. Renal Physiology·Yu-Jung LeeTae-Hwan Kwon
Jun 15, 2007·Annals of Medicine·Richard W TroughtonM Gary Nicholls

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Jun 11, 2010·Current Opinion in Cardiology

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