Effects of dihydroergotamine and sumatriptan on isolated human cerebral and peripheral arteries and veins

Acta Anaesthesiologica Scandinavica
F NilssonC-H Nordström

Abstract

Pharmacological cerebral vasoconstriction has recently been suggested as treatment for patients with increased intracranial pressure (ICP) after severe traumatic brain lesions. Hypothetically, a moderate constriction of precapillary resistance vessels might be advantageous since it decreases intracapillary blood pressure, and a contraction of cerebral veins might effectively reduce intracranial blood volume and ICP. This report examines the in vitro effects of two vasoconstrictors, dihydroergotamine (DHE) and sumatriptan, which may be considered for treatment of increased ICP. The reactivity of isolated small human cerebral subcutaneous and omental arteries and veins were studied during exposure to different concentrations of DHE and sumatriptan. Both sumatriptan and DHE induced concentration-dependent contractions in human cerebral arteries and veins and 50% of maximum contractions were obtained at significantly lower concentrations of DHE than of sumatriptan. The maximum contraction of cerebral arteries was significantly higher with sumatriptan than with DHE. Both drugs caused contractions of subcutaneous arteries at concentrations of 10(-7)-10(-6)M, which is within the therapeutic concentration range of sumatriptan, while no...Continue Reading

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Citations

Oct 3, 2008·Neurosurgical Focus·Timothy Y TranJohn W German
Aug 27, 2005·Journal of Neurosurgery·Carl-Henrik Nordström
Feb 6, 2016·Fluids and Barriers of the CNS·Marc R Del Bigio, Domenico L Di Curzio
May 14, 2014·British Journal of Pharmacology·Roshni Ramachandran, Tony L Yaksh
Aug 1, 2014·Cephalalgia : an International Journal of Headache·Sieneke LabruijereAntoinette MaassenVanDenBrink
Jan 28, 2003·Journal of Cardiovascular Pharmacology·Husamettin GulDervis Sen
Jul 5, 2017·Frontiers in Neurology·Carl-Henrik NordströmMagnus Olivecrona

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