PMID: 1884720Jan 1, 1991Paper

Effects of diltiazem and metoprolol on blood pressure, adverse symptoms and general well-being. The Swedish Diltiazem-Metoprolol Multi-Centre Study Group

European Journal of Clinical Pharmacology
C DahlöfS O Olsson


General well-being, adverse effects and anti-hypertensive efficacy have been investigated in a double blind, parallel-group, dose-response multicentre study of diltiazem and metoprolol monotherapy for hypertension. 128 patients with primary hypertension were included from 10 participating centres. The patients were randomized to receive oral diltiazem 120-240-360 mg/day or metoprolol 50-100-200 mg/day. Each dose was given for a 4-week period as a forced titration regime. In all 119 patients, 59 and 60, respectively, on diltiazem and metoprolol completed the study protocol. There were dose-dependent reductions in supine and standing blood pressures (BP) after both diltiazem and metoprolol therapy. In the diltiazem group, supine BP was reduced by 10 (11)/10 (6) mmHg (SBP/DBP) at the highest dose level, and the corresponding values for the metoprolol group were 7 (16)/8 (9) mmHg (SBP/DBP). Target pressures (DBP less than or equal to 90 mmHg and/or a reduction in DBP of greater than or equal to 10%) were reached in 63% and 48% of the patients, respectively. The incidence and severity of dose-dependent adverse effects, as evaluated by spontaneous reports or open and direct questioning, did not differ between treatments. Subjective w...Continue Reading


Feb 1, 1976·British Heart Journal·C J BulpittS Carne
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice
Apr 1, 1988·Archives of Internal Medicine·F M GengoP R Kinkel
Jun 26, 1986·The New England Journal of Medicine·S H CroogG H Williams
Jan 1, 1984·British Journal of Clinical Pharmacology·M J VandenburgW D Cooper
Aug 1, 1982·British Journal of Clinical Pharmacology·S FreestoneL E Ramsay
Nov 15, 1980·British Medical Journal·D G Altman

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