Effects of diltiazem on isoproterenol- or Ca-induced ventricular myocardial cell injuries in isolated perfused rabbit heart: an electron microscopic study

The Anatomical Record
H D Kim, B J Rah

Abstract

The ultrastructural changes of isoproterenol- and those of Ca-induced ventricular cell injuries were compared in rabbits and the effect of diltiazem on these injuries was studied by electron microscopy. In comparison with the controls, the isoproterenol-treated (Group A), the Ca-treated (Group B), and the diltiazem-posttreated (Groups E and F) showed severe myocardial cell damage, such as sarcolemmal disruption, mitochondrial swelling, intramitochondrial electron-dense granules, membranous structures along mitochondrial cristae, thickening or close packing of the Z-lines, separation of cell junctions, frayed myofibrils, clumping of chromatin, and intracellular fluid accumulation. These ultrastructural changes were more pronounced in the Ca-treated (Groups B and F) than in the isoproterenol-treated (Groups A and E) animals. In contrast, the diltiazem-pretreated groups (Groups C and D) showed relatively intact myocardial ultrastructure. However, intramitochondrial electron-dense granules could be frequently found, and particularly the diltiazem-pretreated and Ca-treated group (Group D) showed intracellular fluid accumulation. The results of this study could suggest the following: 1) isoproterenol-induced myocardial cell damage is...Continue Reading

References

Jul 1, 1979·The American Journal of Cardiology·A M Katz, H Reuter
Aug 1, 1979·Journal of Molecular and Cellular Cardiology·T Toyo-Oka, T Masaki
Mar 1, 1976·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L M BujaJ T Willerson
Jul 1, 1979·Journal of Molecular and Cellular Cardiology·W G NaylerA Williams
Jun 1, 1979·The American Journal of Cardiology·R WeishaarR J Bing
Jul 1, 1985·Journal of Molecular and Cellular Cardiology·L H OpieR Barsacchi
Apr 1, 1986·Journal of Molecular and Cellular Cardiology·M Borgers, H M Piper
Apr 1, 1985·Journal of Molecular and Cellular Cardiology·G Rona
Mar 1, 1986·Journal of Molecular and Cellular Cardiology·S M Humphrey, M A Vanderwee
Apr 1, 1985·Journal of Molecular and Cellular Cardiology·V PanagiaN S Dhalla
Aug 1, 1985·Journal of Molecular and Cellular Cardiology·J A WattsP C Maiorano
Sep 20, 1973·The American Journal of Cardiology·A M Katz
Dec 1, 1969·The American Journal of Cardiology·R B Jennings
Feb 1, 1983·Journal of Molecular and Cellular Cardiology·S KanayaL M Hondeghem
Jul 15, 1980·The Biochemical Journal·R M Allan, E Welman
Jun 1, 1982·Journal of Molecular and Cellular Cardiology·M AshrafA Schwartz
Apr 1, 1981·Journal of Molecular and Cellular Cardiology·S R JollyG J Gross
Jan 1, 1982·Biophysical Journal·T A SteitzD M Engelman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.