PMID: 11899192Mar 20, 2002Paper

Effects of dilutional and modified ultrafiltration in plasma endothelin-1 and pulmonary vascular resistance after the Fontan procedure

The Annals of Thoracic Surgery
Takeshi HiramatsuMakoto Nakazawa

Abstract

Pulmonary vascular resistance (PVR) is closely related with patients' hemodynamics after the Fontan procedure and endothelin-1 (ET-1) may play an important role in pulmonary circulation. Modified ultrafiltration (MUF) is known to remove inflammatory mediators after cardiopulmonary bypass (CPB) surgery. The time courses of plasma ET-1 and PVR were examined before and after the Fontan procedure with MUF. Twenty-two patients who underwent the Fontan procedure were divided into two groups: a dilutional ultrafiltration/modified ultrafiltration (DUF/MUF) group (n =11) and a control group (n = 11). Conventional ultrafiltration was performed during CPB in the control group. DUF was performed semicontinuously during CPB and MUF was continued until 15 to 20 minutes after the CPB with polyacrylonitonile membrane in the DUF/ MUF group. The plasma ET-1 concentration was measured before and after CPB, after MUF in the DUF/MUF group, and 6 and 24 hours after CPB. PVR was calculated simultaneously using a thermodilutional catheter. Plasma ET-1 levels increased significantly after CPB in the control group but they did not increase immediately after CPB in the DUF/MUF group. Similarly, PVR increased significantly after CPB in the control group b...Continue Reading

Citations

Apr 1, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Yasuhiro KotaniHiroshi Date
Jun 3, 2004·The Journal of Thoracic and Cardiovascular Surgery·Pascal A BerdatThierry Carrel
Dec 5, 2006·The Journal of Thoracic and Cardiovascular Surgery·Glyn D WilliamsVadiyala M Reddy
Nov 22, 2008·The Annals of Thoracic Surgery·Emile A BachaDoff B McElhinney
May 29, 2003·The Journal of Thoracic and Cardiovascular Surgery·Gábor SzabóSiegfried Hagl
Nov 10, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Taka-aki NakadaKen-ichi Matsuda
Jul 27, 2006·Asian Cardiovascular & Thoracic Annals·Shahzad G RajaJames Pollock

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