Effects of dimethyl propranolol (UM-272; SC-27761) on myocardial ischemic injury in the canine heart after temporary coronary artery occlusion

D D Ku, B R Lucchesi


Myocardial ischemic injury after temporary occlusion of the left anterior descending coronary artery (LAD) for 90 min followed by reperfusion was estimated from the epicardial ST-segment elevation 15 min after occlusion (ST15m), changes in QRS complex, myocardial creatine kinase (CPK) activity and nitro-blue-tetrazolium (NBT) staining at 24 hours. At all sites exhibiting ST15m greater than 2 mV, there was a small development of epicardial Q waves after 90 min of occlusion (sigma deltaQ = 6.94 +/- 0.52 mV) and was maintained for 24 hours. Good correlations were obtained between CPK activity at 24 hours and the development of Q waves at 24 hours as well as at 60 min after reperfusion (r = 0.49; N = 56). Pretreatment with UM-272 significantly reduced the development of Q-waves (sigma deltaQ1hr = 2.23 +/- 0.75 mV) which was correlated with less CPK depletion and smaller infarct size as determined on the bais of NBT staining for myocardial tissue dehydrogenases at 24 hours. It appears, therefore, that the assessment of pathoologic Q wave development provides an accurate and early estimate of the extent of the ultimate cardiac damage due to ischemia and that pretreatment with UM-272 exerts a protective effect on the ischemic myocardium.


May 4, 1977·The American Journal of Cardiology·H N HultgrenJ Bilisoly
Jun 1, 1977·American Heart Journal·J T BiggerR H Heissenbuttel
May 26, 1977·The American Journal of Cardiology·B Lown, T B Graboys
May 1, 1975·Journal of Molecular and Cellular Cardiology·D J HearseD Border
Mar 31, 1976·The American Journal of Cardiology·B E SobelK B Larson
Jan 1, 1974·The American Journal of Cardiology·G F BresnahanB E Sobel
Jan 31, 1969·Annals of the New York Academy of Sciences·R B JenningsJ P Kaltenbach
Sep 1, 1966·The American Journal of Cardiology·S WolfsonR Gorlin
Nov 1, 1954·The American Journal of Medicine·R P GRANT, R H MURRAY
Dec 1, 1964·American Heart Journal·D DURRERJ BUELLER


Feb 13, 2002·NMR in Biomedicine·Ingrid M Straeter-KnowlenWilliam T Evanochko
Jan 1, 1981·European Journal of Drug Metabolism and Pharmacokinetics·L AllanR F Palmer
Aug 1, 1979·European Journal of Pharmacology·D D Ku, B R Lucchesi
Mar 4, 1983·European Journal of Pharmacology·B T EllerB R Lucchesi
Aug 19, 1982·The New England Journal of Medicine·R M Norris
Jan 1, 1980·Pharmacology & Therapeutics·S D Seth

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