PMID: 38940Jul 1, 1979

Effects of diphosphonate and colchicine administration upon acid-base changes induced in rats by bilateral nephrectomy

Clinical Science
A Goulding, M F Broom

Abstract

1. The effects of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) and colchicine on acid--base balance were examined in intact and nephrectomized rats. 2. Both drugs increased extracellular hydrogen ion concentrations and depressed extracellular bicarbonate concentrations in nephrectomized rats compared with controls but did not alter these parameters in intact animals. 3. Intracellular hydrogen ion concentrations in the skeletal muscle of nephrectomized rats given EHDP were higher than those of control animals. 4. It is postulated that colchicine and EHDP inhibit skeletal buffering of non-volatile acids produced endogenously in nephrectomized rats.

References

Dec 21, 2017·PloS One·Luiz Jardim de QueirozJuan I Montoya-Burgos
Jan 1, 1989·Calcified Tissue International·H Freudiger, J P Bonjour
Jul 14, 2016·Brazilian Journal of Biology = Revista Brasleira De Biologia·F K Siqueira-SouzaC E C Freitas
Jul 20, 2005·Brazilian Journal of Biology = Revista Brasleira De Biologia·M A H PennaM Petrere-Jr

Related Concepts

Carmol
Potassium
Nephrectomy
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Uremia
Anion Gap
Acids
Colchicine, (R)-Isomer
Hydroxyproline

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