PMID: 6405606May 15, 1983Paper

Effects of disopyramide on left ventricular function: assessment by radionuclide cineangiography

The American Journal of Cardiology
J S GottdienerR D Fletcher

Abstract

To determine the effects of disopyramide on resting systolic left ventricular (LV) function and LV functional reserve, gated equilibrium radionuclide cineangiography was performed at rest and during maximal symptom-limited supine bicycle exercise in 12 patients after a single 300 mg oral loading dose of disopyramide, and in 22 patients (including the 12 patients just mentioned) after they received disopyramide 150 mg 4 times daily for 5 to 10 days (average 7). The oral loading dose (average serum level 3.6 +/- 1.3 micrograms/ml [standard deviation] produced decreases in ejection fraction in 9 of 12 patients with a decrease in average resting ejection fraction from 40 +/- 15% to 33 +/- 11% (p less than 0.005). However, the lower, sustained dosage of disopyramide was associated with a lower average serum level of 2.5 +/- 0.8 micrograms/ml and with smaller but significant decreases in ejection fraction in 3 of 22 patients during exercise only. At this dosage there was no significant decrease in average ejection fraction for the group at rest or during exercise. Adverse effects of disopyramide on ejection fraction occurred even in patients with previously normal LV function at rest. Hence, disopyramide may be associated with signif...Continue Reading

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Citations

Nov 1, 1991·Journal of Clinical Pharmacology·H FruminN Kerin
Sep 1, 1995·Journal of the American College of Cardiology·H MatsubaraK Miyatake
Dec 1, 1990·British Journal of Pharmacology·N KondoS Shibata
Jun 1, 1990·The American Journal of Cardiology·S MilsteinW J Reyes
Dec 5, 1989·The American Journal of Cardiology·L Seipel, H M Hoffmeister
Jan 15, 1988·The American Journal of Cardiology·R DiBianco
Apr 20, 2005·Journal of the American College of Cardiology·Mark V SherridBarry J Maron
Jan 1, 1985·Acta Anaesthesiologica Scandinavica·A FischerströmG Settergren
Jul 1, 1988·The Journal of International Medical Research·P P Kenedi

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