PMID: 8947325Nov 1, 1996Paper

Effects of disulfiram on positron emission tomography and neuropsychological studies in severe chronic alcoholism

Alcoholism, Clinical and Experimental Research
S GilmanE Hill

Abstract

Disulfiram is an aldehyde dehydrogenase inhibitor that is widely used as an adjunctive agent in the treatment of patients with severe chronic alcoholism. Recent positron emission tomography (PET) studies of local cerebral metabolic rates for glucose (ICMRglc) and benzodiazepine receptor binding in alcoholic patients have shown regional cerebral abnormalities; however, some of the patients were studied while receiving disulfiram, which could influence the biochemical processes under investigation. In a retrospective investigation, we examined the influence of disulfiram administration on the results of PET studies of ICMRglc and benzodiazepine receptor binding and neuropsychological tests of cognition and executive function in patients with severe chronic alcoholism. [18F]Fluorodeoxyglucose was used to measure ICMRglc in 48 male patients, including 11 receiving and 37 not receiving disulfiram in therapeutic doses. [11C]Flumazenil was used to measure benzodiazepine receptor binding in 17 male patients, including 3 receiving and 14 not receiving disulfiram. All patients studied with FMZ were also examined with fluorodeoxyglucose. PET studies of ICMRglc revealed significantly decreased global values in the patients receiving disulf...Continue Reading

References

Jan 1, 1978·Annals of the New York Academy of Sciences·B StimmelR Hanbury
Jan 1, 1992·Acta Psychiatrica Scandinavica. Supplementum·B Johansson
Jan 1, 1992·Acta Psychiatrica Scandinavica. Supplementum·H Enghusen PoulsenM Andersen
Jan 1, 1992·Acta Psychiatrica Scandinavica. Supplementum·E N Petersen
Aug 1, 1992·The American Journal of Psychiatry·N D VolkowA P Wolf
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A KoeppeD E Kuhl
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·V A HolthoffD E Kuhl
Jun 1, 1991·Alcoholism, Clinical and Experimental Research·T L JerniganL S Cermak
Oct 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·C Harper, D Corbett
Jan 1, 1989·Acta Neuropathologica·J J Kril, C G Harper
Aug 1, 1989·Journal of the Neurological Sciences·C Harper, J Kril
Aug 15, 1985·Biochemical Pharmacology·B Johansson, Z Stankiewicz
Oct 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·Y SamsonC Crouzel
Jun 1, 1986·Alcoholism, Clinical and Experimental Research·P L CarlenG Wortzman
Sep 1, 1985·Alcoholism, Clinical and Experimental Research·V PishkinL E Bourne
Jan 1, 1983·Acta Psychiatrica Scandinavica. Supplementum·T Ishii
Mar 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G D HutchinsR J Nickles
Sep 1, 1982·Brain : a Journal of Neurology·M A RonW A Lishman
May 7, 1982·Science·R C Vallari, R Pietruszko
Nov 1, 1982·Journal of the Neurological Sciences·A TorvikS Rogde
Nov 1, 1982·Journal of Studies on Alcohol·H A Skinner, W J Sheu
Feb 1, 1994·The American Journal of Psychiatry·N D VolkowA P Wolf
Nov 1, 1955·Current Researches in Anesthesia & Analgesia·C B COURVILLE
Jan 1, 1986·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·G RattanW E Fischer
Jan 1, 1950·Scandinavian Journal of Clinical and Laboratory Investigation·L ELDJARN

❮ Previous
Next ❯

Citations

Sep 18, 2007·Neuropsychology Review·Marlene Oscar-Berman, Ksenija Marinković
Aug 26, 1998·Drug and Alcohol Dependence·S J Gatley, N D Volkow
Jun 1, 1997·Journal of Clinical and Experimental Neuropsychology·D Johnson-GreeneM Heumann
Apr 1, 2010·PET Clinics·Andrew B Newberg, Abass Alavi
Jul 23, 2011·Alcoholism, Clinical and Experimental Research·Mira Bühler, Karl Mann
Jul 1, 1999·The Psychiatric Clinics of North America·P NetrakomL A O'Tuama
Mar 3, 2020·Frontiers in Neuroscience·Asha Jacob, Ping Wang
Mar 19, 2019·Frontiers in Psychiatry·Kevin Butler, Bernard Le Foll

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.