Effects of diuretic and beta-blocker therapy in the Medical Research Council Trial

The American Journal of Medicine
G GreenbergW E Miall


The Medical Research Council's treatment trial for mild hypertension was designed to determine the effects of blood pressure reduction on cardiovascular morbidity and mortality rather than to compare the separate effects of thiazides and beta-adrenergic blocking agents. However, the simultaneous use of both active treatments was discouraged and comparisons in terms of blood pressure control, adverse drug reactions, and drug-related changes in the serum biochemistry are possible. The net differences in systolic and diastolic pressure between treated and control subjects were greater in older than in younger people; this net difference was more pronounced in the older people assigned at random to receive bendrofluazide as opposed to propranolol; this effect increased with time during the trial. The need for a supplementary drug (methyldopa) to control blood pressure at target level, was greater in the thiazide-treated group for all ages. Withdrawal from randomized treatment due to adverse reactions was greater in men receiving bendrofluazide than in those receiving propranolol, and greater for women receiving propranolol than in those receiving bendrofluazide. Thiazide treatment was shown, in a sub-study, to be associated with a ...Continue Reading


Apr 1, 1981·The American Journal of Medicine·O B HollandL Kuhnert
Apr 1, 1960·Circulation·W F WEAVER, H B BURCHELL

❮ Previous
Next ❯


Jan 1, 1989·European Journal of Clinical Pharmacology·B J LipworthD G McDevitt
Oct 1, 1989·Cardiovascular Drugs and Therapy·O RománA Valenzuela
Nov 1, 1990·The British Journal of Ophthalmology·J West, S Longstaff
Feb 14, 1986·The American Journal of Medicine·M H Weinberger
Mar 1, 1991·The American Journal of Medicine·K O'MalleyE O'Brien
Apr 22, 1991·The American Journal of Cardiology·P FerrariP Weidmann
Jan 22, 2014·Expert Opinion on Pharmacotherapy·Juan TamargoLuis M Ruilope
Nov 1, 1989·American Heart Journal·W B Kannel, B L Carter
Apr 17, 2016·British Journal of Clinical Pharmacology·Charles KhouriMatthieu Roustit
Sep 1, 1990·The American Journal of the Medical Sciences·W G Thompson
Jun 1, 1991·The American Journal of the Medical Sciences·M J Horan
Mar 1, 1985·Hypertension·D Hyman, N M Kaplan
Jul 23, 2003·Journal of Human Hypertension·A Della ChiesaO M Hess
Oct 1, 1989·Journal of the American College of Nutrition·K Radack, C Deck
Jun 25, 2014·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Valentina TrimarcoNicola De Luca
Mar 1, 1997·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·A U Teuscher, P U Weidmann
Aug 1, 1988·British Journal of Clinical Pharmacology·W R McNabbA F Lant
Sep 1, 1993·The Annals of Pharmacotherapy·D G LabrecheJ L Bauman
Aug 1, 1996·The American Journal of the Medical Sciences·E C MaduT D Fraker
Jan 5, 2000·American Heart Journal·M R Weir, M Moser
Mar 1, 1994·Progress in Cardiovascular Diseases·J H Pinkney, J S Yudkin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.