Effects of diuretic therapy and exercise-related arrhythmias in systemic hypertension.

The American Journal of Cardiology
V PapademetriouE D Freis

Abstract

The effect of aerobic exercise on cardiac arrhythmias, plasma catecholamines, potassium and magnesium in patients with systemic hypertension was assessed. Twenty patients (age 54 +/- 8 years) with uncomplicated hypertension underwent exercise treadmill testing twice while receiving placebo and twice while receiving hydrochlorothiazide 100 mg daily. Blood samples for electrolytes and catecholamines were obtained at rest, at peak exercise and 10 minutes after exercise. There were no substantial differences comparing the first to the second placebo phase or the first to the second treatment period. As expected, hydrochlorothiazide treatment caused a significant decrease in serum potassium (4.00 +/- 0.44 to 3.32 +/- 0.49 mEq/liter, p less than 0.001). Serum magnesium did not change with treatment. Serum potassium, serum magnesium and plasma catecholamines increased significantly with exercise. No rebound hypokalemia occurred during recovery. Occasional ventricular premature contractions were noted at rest during all phases of the study, with only a slight increase in frequency during exercise. Couplets were noted only rarely. No difference in the frequency or complexity of arrhythmias was noted between placebo and treatment periods...Continue Reading

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Citations

Jul 1, 1993·British Journal of Clinical Pharmacology·D L Davies, R Fraser
Aug 1, 1994·British Heart Journal·L Storstein
Jun 10, 2004·Journal of the American Medical Informatics Association : JAMIA·Ashish AtrejaC Martin Harris
Jan 5, 2006·British Journal of Clinical Pharmacology·J A ClaytonI P Hall
Feb 14, 2006·The Journal of Clinical Hypertension·Vasilios Papademetriou
Dec 7, 2007·Clinical and Experimental Hypertension : CHE·Dimitris P Papadopoulos, Vasilios Papademetriou

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