PMID: 9557805Apr 29, 1998Paper

Effects of dobutamine on isovolumic and ejection phase indices of cardiac contractility in conscious healthy dogs

Research in Veterinary Science
K McEnteeM Henroteaux

Abstract

The aim of this study was to determine cardiac contractility using indices derived from cardiac catheterisation in conscious healthy dogs during dobutamine infusion. Eight dogs were studied. An ECG was recorded together with left ventricular pressure and volume which were measured using a conductance catheter with an integrated microtip pressure sensor. Eight indices of left ventricular systolic performance were derived from these records. Measurements were realised under basal conditions and during an incremental dobutamine challenge. The maximal rate of rise in ventricular pressure (max dP/dt), max dP/dt divided by the developed pressure and the mean systolic ejection rate were the most sensitive indices to detect dobutamine induced changes in contractility with maximal percentage changes of 122+/-11 per cent, 130+/-7 per cent and 102+/-24 per cent respectively. Ejection fraction increased significantly during dobutamine infusion (maximal percentage change of 43+/-9 per cent) whereas the pre-ejection period (PEP) and the left ventricular ejection time (LVET) decreased significantly (maximal percentage change of -41+/-2 per cent and -28+/-3 per cent respectively). All these six indices were significantly correlated with each o...Continue Reading

References

Aug 1, 1977·Circulation·R P LewisH Boudoulas
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Nov 1, 1996·Research in Veterinary Science·K McEnteeM Henroteaux

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Citations

Dec 1, 2000·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·K Mc EnteeM Henroteaux
Aug 7, 2001·Journal of Cardiovascular Pharmacology·J D OvercastS W May
Apr 24, 2009·Statistics in Medicine·Susan A Alber, Robert E Weiss
Jun 21, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Siyuan LiuMark D Rollins

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