PMID: 9176830Jun 1, 1997Paper

Effects of docosahexaenoic acid on serum lipoproteins in patients with combined hyperlipidemia: a randomized, double-blind, placebo-controlled trial

Journal of the American College of Nutrition
M H DavidsonK B Drennan

Abstract

The objective of this study was to evaluate the effects of daily dietary supplementation with 1.25 g or 2.5 g of docosahexaenoic (DHA), in the absence of eicosapentaenoic acid (EPA), on serum lipids and lipoproteins in persons with combined hyperlipidemia (CHL) [serum low-density lipoprotein cholesterol (LDL-C) 130 to 220 mg/dL and triglycerides 150 to 400 mg/dL]. After a 6-week dietary stabilization period, subjects entered a 4-week single-blind placebo (vegetable oil) run-in phase. Those with adequate compliance during the the run-in were randomized into one of three parallel groups (placebo, 1.25, or 2.5 g/day DHA) for 6 weeks of treatment. Supplements were administered in a triglyceride form contained in gelatin capsules. Primary outcome measurements were plasma phospholipid DHA content, serum triglycerides, high-density lipoprotein cholesterol (HDL-C). LDL-C and non-HDL-C. The DHA content of plasma phospholipids increased dramatically (2 to 3 fold) in a dose-dependent manner. Significant (p < 0.05) changes were observed in serum triglycerides (17 to 21% reduction) and HDL-C (6% increase) which were of similar magnitude in both DHA groups. Non-HDL-C [+1.6 (NS) and +5.7% (p < 0.04)] and LDL-C [+9.3% (NS) and +13.6% (p < 0.00...Continue Reading

Citations

Jul 10, 2010·Cardiovascular Drugs and Therapy·Rafael BitzurArdon Rubinstein
Dec 21, 2000·Current Atherosclerosis Reports·P Nestel
Sep 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Robert KroesGary M Williams
Feb 24, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L M ArterburnD J Kyle
Jan 19, 2007·Journal of the American College of Nutrition·Lisa J SchwellenbachUNKNOWN Clinical Pharmacy Cardiac Risk Service Study Group
Aug 16, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Kevin C MakiJeffrey G Geohas
Nov 16, 2013·International Journal of Food Sciences and Nutrition·Elvira VerduciMarcello Giovannini
May 22, 2010·Annals of Medicine·Christopher P F Marinangeli, Peter J H Jones
Jun 9, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Eric L Lien
Aug 22, 2006·The American Journal of Cardiology·Michael H Davidson
Sep 10, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·L A Horrocks, Y K Yeo
Oct 14, 2016·Metabolism: Clinical and Experimental·Ivor B AsztalosErnst J Schaefer
Dec 16, 1998·The British Journal of Nutrition·G HornstraP M Verschuren
Mar 31, 2006·The British Journal of Nutrition·Julia GeppertBerthold Koletzko
Feb 4, 2003·Journal of Lipid Research·Yongsoon Park, William S Harris
Oct 19, 2006·The Annals of Pharmacotherapy·Leslie K NiesKari L Olson
Feb 16, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Trevor A Mori, Richard J Woodman
Nov 1, 2001·The Cochrane Database of Systematic Reviews·E LonerganJ Colford
Oct 31, 2001·The American Journal of Clinical Nutrition·E Dewailly EB J Holub
May 11, 2007·The American Journal of Clinical Nutrition·Alison M HillPeter R C Howe
Mar 31, 2004·The American Journal of Clinical Nutrition·Hannah E TheobaldThomas A B Sanders
Jul 7, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Hui-Jun ZhangDuo Li

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