Effects of dopamine antagonists on changes in spontaneous EEG and locomotor activity in ketamine-treated rats

Pharmacology, Biochemistry, and Behavior
M YamamotoM Suzuki

Abstract

We investigated the effects of dopamine antagonists on spontaneous cortical and hippocampal electroencephalographic (EEG) changes, and on hyperlocomotion in ketamine-treated rats. Ketamine (20-60 mg/kg IP) synchronized cortical EEG and desynchronized hippocampal EEG in a dose-dependent manner indicating that the drug induced a dissociation between the cortical and hippocampal EEG. These EEG changes were accompanied by an increase in spontaneous locomotor activity, which involved lack of focused direction, stereotypy, irritability and other abnormalities. Dopamine antagonists, such as haloperidol (0.3-1 mg/kg IP), and nemonapride (0.3-1 mg/kg IP), reversed the dissociation between the cortical and hippocampal EEG in ketamine (60 mg/kg IP)-treated rats. Ketamine-induced hyperlocomotion was also decreased by administration of haloperidol (0.3 and 1 mg/kg IP) or nemonapride (0.1-1 mg/kg IP). Thus, it was found that dopamine antagonists reversed the EEG alterations and behavioural changes in ketamine-treated rats.

References

Jun 1, 1978·Neuropharmacology·L VargiuG Saba
Aug 17, 1979·Brain Research·M MyslobodskyV Golovchinsky
Jan 1, 1976·Acta Anaesthesiologica Scandinavica·P YlitaloL Ahtee
Jan 1, 1992·Psychosomatics·P T TrzepaczK Ciongoli
Jan 1, 1991·International Psychogeriatrics·L E Tune, F W Bylsma
Jan 1, 1991·International Psychogeriatrics·A F Leuchter, S A Jacobson
Jan 1, 1990·Journal of General Internal Medicine·J Francis, W N Kapoor
Feb 18, 1989·BMJ : British Medical Journal
Jan 1, 1989·The Journal of Neuropsychiatry and Clinical Neurosciences·P T TrzepaczD H Van Thiel
Aug 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·H KoponenP J Riekkinen
May 1, 1985·Pharmacology, Biochemistry, and Behavior·K M Johnson, L D Snell
Apr 1, 1985·Pharmacology, Biochemistry, and Behavior·B E Hetzler, B S Wautlet
Jun 1, 1966·The Journal of Nervous and Mental Disease·M M GrossI Kishner
Nov 19, 1981·European Journal of Pharmacology·R D SturgeonH Y Meltzer
Feb 1, 1982·Anesthesiology·P F WhiteA J Trevor
May 1, 1965·Clinical Pharmacology and Therapeutics·E F DOMINOG CORSSEN

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Citations

Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Christopher WilsonJean Sumner
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·A YilmazR Canbeyli
Sep 10, 2003·Neurochemistry International·Michelle M TsoJonathan A Stamford
Jan 10, 2012·Epilepsy & Behavior : E&B·Raquel Cristina de Sousa LimaSilvânia Maria Mendes Vasconcelos
Apr 3, 2007·Physiology & Behavior·Christopher WilsonAngel McLaurin
Nov 30, 1999·Animal Behaviour· van den Bos R
Nov 1, 2011·Pharmacology, Biochemistry, and Behavior·Kubra AkilliogluAyper Boga

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