Effects of dopamine D3 receptor antagonists on spontaneous and agonist-reduced motor activity in NMRI mice and Wistar rats: comparative study with nafadotride, U 99194A and SB 277011

Behavioural Pharmacology
István Gyertyán, Katalin Sághy

Abstract

Studies investigating the role of the dopamine D3 receptor in the regulation of motor activity of rodents have used several ligands; however, there have been few comparative studies using agonist-antagonist interactions. In the present study, we compared the effects of dopamine D3 antagonists with different levels of selectivity over D2 receptors (nafadotride, U 99194A and SB 277011) on motor activity as well as on agonist-induced hypoactivity, in mice and rats. Horizontal and vertical movements were measured in photocell activity cages. 7-Hydroxy-2-(di-n-propylamino)tetralin (7-OH-DPAT) and PD 128907 were used as dopaminergic agonists. Both dose-dependently inhibited motor activity in mice and vertical activity in rats, while decreasing horizontal activity of rats at doses of 0.01 and 0.1 mg/kg s.c., with no effect (7-OH-DPAT) or stimulation (PD 128907) at the 1 mg/kg dose. In mice habituated to the activity cage, nafadotride (0.1-3 mg/kg i.p.) caused a dose-dependent decrease in motor activity but did not affect the hypomotility evoked by either 7-OH-DPAT (0.1 mg/kg) or PD 128907 (0.1 mg/kg). In habituated rats it had no significant effect on motor activity and was not able to antagonize the hypoactivity caused by PD 128907 (...Continue Reading

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Citations

Mar 14, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Tomek J Banasikowski, Richard J Beninger
May 11, 2010·Pharmacology, Biochemistry, and Behavior·Svenja E SanderAngelika Richter
Sep 22, 2009·Pharmacology, Biochemistry, and Behavior·Steven B Harrod, M Lee Van Horn
Jul 14, 2007·European Journal of Pharmacology·István Gyertyán, Katalin Sághy
Apr 6, 2007·Pharmacology, Biochemistry, and Behavior·Laurel M PritchardNeil M Richtand
Mar 9, 2007·European Journal of Pharmacology·Jennifer E Murray, Rick A Bevins
Jul 12, 2005·Neuropharmacology·Robert L H Clements, Andrew J Greenshaw
Aug 5, 2015·Translational Psychiatry·S J KlenotichS C Dulawa
Jul 5, 2005·Drug Discovery Today·Jeffrey N Joyce, Mark J Millan
Oct 8, 2016·Journal of Neuroscience Research·Peng LiuYong-Hui Dang
May 6, 2008·Journal of Clinical Psychopharmacology·Steven G Potkin
Apr 24, 2019·CNS Spectrums·Francesca CalabreseMarco A Riva
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshiko WatanabeOsamu Yoshie

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