Abstract
Several previous studies have shown that dopamine causes amylase secretion from rat parotid tissue. However, the mechanism of this dopamine action is still unclear. The present study was designed to characterize dopamine action in rat parotid gland tissue by examining the effects of dopamine on cyclic AMP accumulation, adenylyl cyclase activity, and amylase release. Dopamine significantly enhanced accumulation of cyclic AMP in parotid slices and stimulated adenylyl cyclase activity in parotid membrane preparations. It also significantly stimulated amylase release from parotid slices. The stimulatory effects of dopamine on cyclic AMP accumulation, adenylyl cyclase activity, and amylase release were effectively blocked with propranolol, a beta-adrenergic antagonist, but not by either SCH 23390, a preferential D1 antagonist, or butaclamol, a preferential D2 antagonist. No substantial specific binding sites for D1 receptors were detectable by [3H]SCH 23390 binding in parotid membranes. These results suggest that the stimulatory effect of dopamine on amylase secretion in rat parotid tissue is not mediated through specific D1 dopamine receptors but rather through beta-adrenergic receptors.
References
Sep 1, 1992·Journal of Neurochemistry·C VadaszA Fleischer
May 29, 1991·The American Journal of Medicine·M F Lokhandwala, S S Hegde
Dec 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M F Lokhandwala, F Amenta
Nov 1, 1986·British Journal of Pharmacology·F HataE Kondo
Oct 1, 1988·The Journal of Physiology·A DanielssonP Wester
Mar 12, 1985·European Journal of Pharmacology·S SundströmR Henriksson
Jan 12, 1988·European Journal of Pharmacology·S SundströmP Lindström
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S HattaM M Rasenick
Jan 1, 1982·Archives of Oral Biology·K Abe, C Dawes
Dec 1, 1981·Japanese Journal of Pharmacology·H OhshikaM Tanaka
Jan 1, 1993·Psychopharmacology·Y HattaT Saito
Mar 1, 1993·Neurochemistry International·P G Strange
Jan 1, 1993·Fundamental & Clinical Pharmacology·P DenisP Lapalus
Jan 1, 1993·Annual Review of Neuroscience·J A Gingrich, M G Caron
Feb 1, 1993·Trends in Pharmacological Sciences·B Giros, M G Caron
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·O CivelliD K Grandy
Citations
Jun 18, 2014·The Cochrane Database of Systematic Reviews·Munirah YaacobAnne-Marie Glenny
Jul 3, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniele TomassoniFrancesco Amenta
Apr 24, 2019·International Journal of Environmental Research and Public Health·Declan Timothy Waugh
Apr 13, 2021·Investigative Ophthalmology & Visual Science·Yong Woo JiHyung Keun Lee