Effects of dopamine on oxygen consumption and gastric mucosal blood flow during cardiopulmonary bypass in humans

British Journal of Anaesthesia
W KarzaiH J Priebe

Abstract

We investigated the effects of flow rate and dopamine on systemic oxygen delivery (DO2) oxygen consumption (VO2) and gastric mucosal microcirculatory blood flow (gMCF), measured by laser Doppler flowmetry in 12 patients undergoing mild hypothermic (34 degrees C) cardiopulmonary bypass (CPB). The first intervention comprised increasing CPB flow rates from 2.4 to 3.0 litre min-1 m-2, and the second intervention administering dopamine 6 micrograms kg-1 min-1. Measurements were made before and 10 min after the start of one of the two interventions. The heart remained in cardioplegic arrest throughout the study. There were no significant differences in variables between the two baseline measurements preceding the interventions. The increase in CPB flow rate increased DO2 and gMCF without affecting VO2. At constant flow rate, dopamine also increased gMCF with no change in VO2, DO2 or mean arterial pressure. Our data suggested that dopamine had no flow-independent effect on VO2 and that it increased gMCF during constant flow hypothermic CPB.

Citations

May 2, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Rajeshwara Krishna Prasad AdluriIan Moore Mitchell
Apr 10, 2002·Critical Care Medicine·Thomas W L ScheerenArtur Fournell
Jul 9, 2003·Critical Care Medicine·Lothar A SchwarteThomas W L Scheeren
Mar 27, 2001·Transplant International : Official Journal of the European Society for Organ Transplantation·E RønholmA Aneman
Sep 17, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Nick J KoningChrista Boer
Sep 1, 1999·Journal of Cardiothoracic and Vascular Anesthesia·P D BookerC F Whitehead
Jan 16, 2008·Current Opinion in Anaesthesiology·Andrew Ian LevinAndre Coetzee

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