PMID: 6171257Jan 15, 1981Paper

Effects of dopamine on prolactin secretion and cyclic AMP accumulation in the rat anterior pituitary gland

The Biochemical Journal
K P Ray, M Wallis

Abstract

The effects of dopamine on pituitary prolactin secretion and pituitary cyclic AMP accumulation were studied by using anterior pituitary glands from adult female rats, incubated in vitro. During 2h incubations, significant inhibition of prolactin secretion was achieved at concentrations between 1 and 10nm-dopamine. However, 0.1-1mum-dopamine was required before a significant decrease in pituitary cyclic AMP content was observed. In the presence of 1mum-dopamine, pituitary cyclic AMP content decreased rapidly to reach about 75% of the control value within 20min and there was no further decrease for at least 2h. Incubation with the phosphodiesterase inhibitors theophylline (8mm) or isobutylmethylxanthine (2mm) increased pituitary cyclic AMP concentrations 3- and 6-fold respectively. Dopamine (1mum) had no effect on the cyclic AMP accumulation measured in the presence of theophylline, but inhibited the isobutylmethylxanthine-induced increase by 50%. The dopamine inhibition of prolactin secretion was not affected by either inhibitor. Two derivatives of cyclic AMP (dibutyryl cyclic AMP and 8-bromo cyclic AMP) were unable to block the dopamine (1mum) inhibition of prolactin secretion, although 8-bromo cyclic AMP (2mm) significantly st...Continue Reading

Citations

Mar 1, 1983·Clinics in Endocrinology and Metabolism·M J Cronin, W S Evans
Apr 1, 1985·Medicinal Research Reviews·C Kaiser, T Jain
Jun 1, 1987·Journal of Endocrinological Investigation·B VelkeniersL Vanhaelst
Oct 1, 1985·The American Journal of Physiology·J M AndersonM J Cronin
Nov 1, 1982·Molecular and Cellular Endocrinology·K P Ray, M Wallis
Jun 1, 1984·Molecular and Cellular Endocrinology·K P Ray, M Wallis
Jul 1, 1982·Molecular and Cellular Endocrinology·K P Ray, M Wallis
Mar 1, 1984·Metabolism: Clinical and Experimental·S TornelloA F De Nicola

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