PMID: 1212559Dec 1, 1975Paper

Effects of dopamine on sinus rate and ventricular contractile force of the dog heart in vitro and in vivo

British Journal of Pharmacology
M Endoh

Abstract

1 Experiments were carried out on dog isolated papillary muscle and sinus node preparations perfused with arterial blood from a donor dog. The chronotropic and inotropic effects of dopamine were analysed by using reserpine, desmethylimipramine (DMI), cocaine and phenoxybenzamine, and the relative chronotropic and inotropic effects defined, the results being compared with those for noradrenaline (NA). 2 The effects of dopamine administered intra-arterially into the isolated preparations were reduced by pretreatment of animals with reserpine both in the papillary muscle and sinus node. The chronotropic effects, however, were affected less by pretreatment with reserpine than were the inotropic effects. 3 Desmethylimipramine (DMI) reduced the inotropic and chronotropic effects of dopamine, and enhanced the effects of NA and nerve stimulation; the chronotropic effects of the amines were less affected than the inotropic effects. 4 Cocaine enhanced considerably the inotropic and chronotropic effects of NA, and decreased the inotropic but not the chronotropic effect of dopamine. 5 Phenoxybenzamine enhanced the inotropic effects of dopamine, NA and nerve stimulation, but did not affect the chronotropic effects of the amines. 6 When dopa...Continue Reading

References

Dec 19, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·P J Neuvonen, E Westermann
Apr 1, 1966·The Journal of Pharmacy and Pharmacology·J B Farmer
May 1, 1970·The American Journal of Physiology·M Endoh, K Hashimoto
Jun 15, 1970·The Japanese Journal of Physiology·M Endo, K Hashimoto
Feb 1, 1972·The Tohoku Journal of Experimental Medicine·M EndohK Hashimoto
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Feb 1, 1962·Circulation Research·D HORWITZL I GOLDBERG

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Citations

Jan 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·Y KogaS M Taylor
Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·M BoucherP Duchêne-Marullaz
Jan 8, 2014·The Journal of Physiology·Piotr NiewinskiPiotr Ponikowski
Sep 22, 2009·Autonomic Neuroscience : Basic & Clinical·Shuji ShimizuMasaru Sugimachi
May 3, 2007·The Journal of Physiological Sciences : JPS·Yoshiakira Wakita
Jun 27, 2006·Journal of Pharmacological Sciences·Masao Endoh
Aug 8, 2015·Chemical Communications : Chem Comm·Hui-Jen LinIan Liau

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