PMID: 2506610Jan 1, 1989Paper

Effects of dopamine receptor antagonists on sucrose consumption and preference

Psychopharmacology
R Muscat, P Willner

Abstract

Effects of the dopamine D2 receptor antagonist sulpiride and the D1 antagonist SCH-23390 were examined, in rats, in two-bottle preference tests (sucrose versus water) and in single-bottle tests, at different sucrose concentrations. Both drugs decreased sucrose intake in single bottle tests, at low sucrose concentrations, but had no effect at high concentrations; reducing drive level had exactly the opposite pattern of effects. In two-bottle tests, both drugs reduced preference for the weakest sucrose concentration (0.7%) but increased preference for the strongest concentration (34%). The effects of antagonizing either subtype of DA receptor appear to be similar to those of reducing the concentration of sucrose.

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Citations

Jan 1, 1990·Psychopharmacology·P WillnerR Muscat
Aug 1, 1990·Biological Psychiatry·R MuscatP Willner
Oct 1, 1991·Pharmacology, Biochemistry, and Behavior·R MuscatP Willner
May 1, 1993·Pharmacology, Biochemistry, and Behavior·A Tyrka, G P Smith
Jan 1, 1995·Pharmacology, Biochemistry, and Behavior·S Hsiao, G P Smith
Sep 1, 1992·Progress in Neurobiology·J R BlackburnA G Phillips
Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·John-Andrews M McQuadeRandy J Seeley
Aug 1, 1997·Physiology & Behavior·F S HallT W Robbins
May 22, 2003·Pharmacology, Biochemistry, and Behavior·Robert M BakerRichard J Bodnar
Jun 4, 1998·Pharmacology, Biochemistry, and Behavior·B A GosnellB J Harasha
Feb 25, 1998·Behavioural Brain Research·J R Blackburn, K K Szumlinski
Dec 5, 2000·Behavioural Pharmacology·B A Ellenbroek, A R Cools
Jan 1, 1997·Annual Review of Psychology·K NaderD van der Kooy
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·R Muscat, P Willner
Jan 18, 2011·Physiology & Behavior·Akira UematsuKunio Torii
Nov 5, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Samuel A BarnesAthina Markou

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