Effects of dopaminergic agents on carrageenan hyperalgesia after intrathecal administration to rats

European Journal of Pharmacology
X GaoG C Wu

Abstract

The present study explored the role of dopaminergic transmission in spinal cord in a model of carrageenan-induced inflammatory pain by examining the effects of selective agonists and antagonists of dopamine receptors. The results were as follows: (1) trans-(-)-4aR-4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrazolo[3,4-g] quinoline hydrochloride (LY171555), a dopamine D(2) receptor agonist, produced anti-hyperalgesia (150 and 300 nmol) or hypoalgesia (300 nmol) in the inflamed hindpaws and non-inflamed hindpaws, respectively; spiperone hydrochloride (8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride), a dopamine D(2) receptor antagonist, decreased the pain threshold of non-inflamed hindpaws (300 nmol). (2) (+/-)-SKF38393 hydrochloride ((+/-)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrochloride), a dopamine D(1) receptor agonist, had no effect on either hindpaw, even at a higher dose (300 nmol); R(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (R(+)-SCH23390 hydrochloride), a dopamine D(1) receptor antagonist, induced anti-hyperalgesia in the inflamed hindpaws (300 nmol). The present results suggest that the dopaminergic system in t...Continue Reading

References

Nov 19, 1985·European Journal of Pharmacology·S Barasi, K N Duggal
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Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS

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Citations

Apr 2, 2010·Journal of Neural Transmission·H-R GaoM-Y Xu
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jun 25, 2014·Brain Research Bulletin·Nuria CobachoCarlos Luis Paíno
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Jan 26, 2007·European Journal of Pharmacology·Darryl T HamamotoDonald A Simone
Oct 16, 2007·European Journal of Pain : EJP·Ulises CoffeenFrancisco Pellicer
Sep 1, 2006·The Journal of Pain : Official Journal of the American Pain Society·Patrick B Wood
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