PMID: 9649174Jul 2, 1998Paper

Effects of dopaminergic drugs, occlusal disharmonies, and chronic stress on non-functional masticatory activity in the rat, assessed by incisal attrition

Journal of Dental Research
F M GómezP García-Vallejo

Abstract

Observational methods and the recording of nonspecific jaw movements or masticatory muscle activity have been used to evaluate oral parafunctional movements in animal models of bruxism. In this study, we have used a new approach in which the non-functional masticatory activity in the rat was assessed by the measurement of incisal attrition, with the aim of investigating the role of diverse factors involved in the etiology of bruxism. We quantified the attrition rate weekly by making superficial notches in the lower incisors and measuring the distances to the incisor edges. Repeated stimulation of the dopaminergic system with apomorphine led to an enhancement of the non-functional masticatory activity (p < 0.0001). The severity of the apomorphine-induced oral behavior was positively correlated (r(s) = 0.69, p < 0.01) with an increase in the incisal attrition rate (20.9%, p < 0.0001). Apomorphine-induced non-functional masticatory activity was strongly enhanced by the placement of an acrylic cap on both lower incisors (306%, p < 0.0001), but not by the cutting of a lower incisor. Repeated cocaine administration also increased the attrition rate (22.5%, p < 0.0001). However, neither chronic blockade of dopaminergic receptors with ...Continue Reading

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Citations

Jan 14, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·E K TanW Ondo
Jan 7, 2004·Journal of the Neurological Sciences·Eng-King TanHui-Meng Chang
Aug 8, 2014·BioMed Research International·Mieszko WieckiewiczWlodzimierz Wieckiewicz
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Feb 13, 2003·Acta Neurologica Scandinavica·S-J See, E-K Tan
Jan 29, 2000·Cranio : the Journal of Craniomandibular Practice·M W WattsJ Jankovic

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