PMID: 9179509Apr 14, 1997Paper

Effects of dopaminergic drugs on food- and cocaine-maintained responding. IV: Continuous cocaine infusions

Drug and Alcohol Dependence
J R Glowa, W E Fantegrossi

Abstract

The effects of cocaine (continuously infused during the session with and without a are-loading dose) on responding maintained under multiple fixed-ratio 30 schedules of limited access to food and cocaine delivery (10 or 56 micrograms/kg per injection) were studied in nine rhesus monkeys. When responding was maintained by 10 micrograms/kg per injection, cocaine decreased rates of cocaine-maintained responding in a dose-related manner while having no effect on food-maintained responding. When responding was maintained by 56 micrograms/kg per injection, cocaine decreased both cocaine- and food-maintained responding. These results show that the effects of continuous infusions of cocaine depend upon both the unit dose of cocaine and the event that maintains responding. As such, the effects of continuous infusions of cocaine are similar to those of other, longer-acting dopamine agonists. Such results support the development of long-acting agonist approaches to the pharmacotherapeutic treatment of cocaine abuse.

References

Jun 1, 1993·Drug and Alcohol Dependence·P SkjoldagerJ H Woods
Jan 1, 1993·Drug and Alcohol Dependence·R S Mansbach, R L Balster
Aug 1, 1995·Molecular Neurobiology·M G Hadfield
Jun 1, 1996·Pharmacology, Biochemistry, and Behavior·L KoetznerJ R Glowa

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Citations

Sep 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew L Banks, S Stevens Negus
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·W A Corrigall
Feb 22, 2002·Behavioural Pharmacology·K L SheltonK A Grant
Feb 4, 2012·Future Medicinal Chemistry·Craig R Rush, William W Stoops
Sep 4, 2004·Addictive Behaviors·John GrabowskiS Stevens Negus
Aug 29, 2006·European Journal of Pharmacology·Gail Pereira Do CarmoS Stevens Negus
Mar 15, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S Stevens Negus
Nov 16, 2006·The Journal of Pharmacology and Experimental Therapeutics·Leonard L HowellHeather L Kimmel
Apr 13, 2013·The Journal of Pharmacology and Experimental Therapeutics·Paul W CzotyMichael A Nader
Apr 2, 2003·Psychopharmacology·David C S RobertsHuw M L Davies

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