Effects of dose escalating liraglutide from 1.2 to 1.8 mg in clinical practice: a case-control study

Journal of Endocrinological Investigation
M RigatoG P Fadini

Abstract

Randomized trials show that liraglutide 1.8 mg is more effective than 1.2 mg in reducing HbA1c, but dose escalation is neither routinely considered nor recommended by some guidelines. We report real world data on the effects of dose-escalating liraglutide from 1.2 to 1.8 mg. In a pseudo-prospective, case-control study, patients who underwent liraglutide dose escalation to 1.8 mg for not having met individualized targets while on the 1.2 mg dose (n = 52) were compared to matched patients who remained on 1.2 mg (n = 52) for having shown good response, as defined by the patient's own diabetologist. HbA1c was recorded at ≤6-month intervals until the end of observation. The two groups were matched for all clinical characteristics, including baseline HbA1c (8.5 %). During a 12-month follow-up, patients who remained on liraglutide 1.2 mg showed a maximal HbA1c reduction of 1.29 ± 0.15 %. Patients who escalated to 1.8 mg showed a lower HbA1c reduction during therapy with 1.2 mg than controls (0.58 ± 0.16 %; p = 0.0017). Escalation to 1.8 mg resulted in a further HbA1c reduction of 0.62 ± 0.17 %. During a total 18-month follow-up, patients who escalated to 1.8 mg showed a total maximal HbA1c reduction of 0.84 ± 0.22 %. At the end of the...Continue Reading

References

Aug 19, 2009·Diabetologia·D Russell-JonesUNKNOWN Liraglutide Effect and Action in Diabetes 5 (LEAD-5) met+SU Study Group
Apr 24, 2012·Journal of Endocrinological Investigation·M A Abdul-GhaniR A DeFronzo
May 28, 2013·Lancet·John E Morley, Alan Sinclair
Jun 12, 2013·Nature Reviews. Endocrinology·Linda Koch
Mar 29, 2014·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Mauro Rigato, Gian Paolo Fadini
Aug 12, 2014·Journal of Endocrinological Investigation·G MuscogiuriA Colao
Mar 17, 2015·The Lancet. Diabetes & Endocrinology·Anthony H Barnett

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Citations

Feb 16, 2016·Cell Metabolism·Midhat H AbdulredaPer-Olof Berggren
Jun 29, 2016·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Amrita OstawalWeiwei Xu
Apr 18, 2018·Current Medical Research and Opinion·Louis S MatzaJessica Jordan
Jul 1, 2020·Journal of Endocrinological Investigation·F FerrariF Santini

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