PMID: 2502798Jan 1, 1989Paper

Effects of dose on effector mechanisms in morphine-induced hyperthermia and poikilothermia

Psychopharmacology
D E JorenbyT B Baker

Abstract

The effect of a variety of morphine doses on thermoregulatory effector systems was examined in ambient temperatures of 27.0 degrees C and 4.0 degrees C. Rats were given saline or morphine sulfate (5, 15, or 25 mg/kg); their core temperature, oxygen consumption, and activity were monitored for 4 or 6 h post-injection. The results suggest two distinct actions of morphine, possibly mediated by two opiate receptors. Low doses of morphine produce hyperthermia that is the result of a direct activation of activity and whole body heat production. High doses produce effects dependent on ambient temperature: hypermetabolism and hyperthermia in the 27.0 degrees C environment; hypometabolism, vasodilation, and hypothermia in the 4.0 degrees C environment. The findings suggest limitations in current set-point theories of morphine's thermic actions.

References

Mar 14, 1979·Psychopharmacology·R Eikelboom, J Stewart
Apr 1, 1979·Pharmacology, Biochemistry, and Behavior·W G Clark
Feb 15, 1979·European Journal of Pharmacology·B CoxM J Vale
Mar 1, 1976·European Journal of Pharmacology·B CoxP Lomax
Jan 1, 1988·Annual Review of Pharmacology and Toxicology·M W AdlerJ Cochin
Jan 1, 1987·Psychopharmacology·R F MuchaC Kim
Dec 1, 1988·Behavioral Neuroscience·D E JorenbyT B Baker
Apr 1, 1983·Pharmacology, Biochemistry, and Behavior·J N McDougalT F Burks
Jan 1, 1981·Progress in Neuro-psychopharmacology·R Numan, H Lal

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Citations

Jan 1, 1992·Psychopharmacology·R Dafters, P Taggart
Nov 1, 1991·Physiology & Behavior·P AbbottM B Kristal
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·M B Kristal
Sep 9, 2016·Journal of Neurophysiology·Nabil El BitarDaniel Le Bars

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