Effects of doxorubicin mediated by gold nanoparticles and resveratrol in two human cervical tumor cell lines

Colloids and Surfaces. B, Biointerfaces
Gheorghe TomoaiaMaria Tomoaia-Cotisel

Abstract

Green synthesis of gold nanoparticles capped with resveratrol (GNPs) and their physical and chemical characterization by UV-vis spectra, FTIR, DLS, XRD, TEM and AFM are reported. The GNPs are highly stable, with average diameter of about 20 nm. Then, supramolecular nanoassemblies of GNPs and doxorubicin (Dox), Dox-GNPs complexes, were prepared and morphologically characterized. The stability of these Dox nanocomplexes is high in phosphate buffer saline as estimated by UV-vis spectra, TEM and AFM analysis. Effects of resveratrol (Resv), Resv-Dox mixtures, GNPs and Dox-GNPs complexes on HeLa and CaSki cells, after 24h drug incubation, were assessed using MTT cell viability assay. Results showed strong anticancer activity for Resv-Dox mixtures and Dox-GNPs complexes in the two human cervical carcinoma cell lines. Clearly, both Resv and GNPs can mediate the anticancer activity of Dox at its very low concentration of 0.1 μg/mL, reaching the cytotoxicity of Dox alone, at its concentration up to 20 times higher. Cytotoxic effects of Resv-Dox mixtures and Dox-GNPs complexes have been found for the first time in HeLa and CaSki cells. Furthermore, the apoptosis induction in HeLa and CaSki cells was evidenced for Resv-Dox mixtures and Dox...Continue Reading

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Citations

May 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Tanira V VerissimoClaure N Lunardi
Jul 23, 2016·Pharmaceutics·Farideh OrdikhaniAbdel Kareem Azab
Dec 22, 2016·Critical Reviews in Food Science and Nutrition·Abdur RaufMohammad S Mubarak
May 18, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Yang KeSuresh Mickymaray
Feb 28, 2020·International Journal of Nanomedicine·Corina GarboMaria Tomoaia-Cotisel
Feb 23, 2019·Journal of Cellular Physiology·Yong-Hong GuanYi-Nan Wang
Feb 16, 2019·Recent Patents on Drug Delivery & Formulation·Zeenat Iqbal, Fahima Dilnawaz
Nov 14, 2020·Clinical Science·Alexa N CarreraBeshay N Zordoky
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicola MicaleAntonio Speciale

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