Effects of Droplet Composition on Nanodroplet-Mediated Histotripsy

Ultrasound in Medicine & Biology
Eli VlaisavljevichMohamed ElSayed

Abstract

Nanodroplet-mediated histotripsy (NMH) is a targeted ablation technique combining histotripsy with nanodroplets that can be selectively delivered to tumor cells. In two previous studies, polymer-encapsulated perfluoropentane nanodroplets were used to generate well-defined ablation similar to that obtained with histotripsy, but at significantly lower pressure, when NMH therapy was applied at a pulse repetition frequency (PRF) of 10 Hz. However, cavitation was not maintained over multiple pulses when ultrasound was applied at a lower PRF (i.e., 1-5 Hz). We hypothesized that nanodroplets with a higher-boiling-point perfluorocarbon core would provide sustainable cavitation nuclei, allowing cavitation to be maintained over multiple pulses, even at low PRF, which is needed for efficient and complete tissue fractionation via histotripsy. To test this hypothesis, we investigated the effects of droplet composition on NMH therapy by applying histotripsy at various frequencies (345 kHz, 500 kHz, 1.5 MHz, 3 MHz) to tissue phantoms containing perfluoropentane (PFP, boiling point ∼29°C, surface tension ∼9.5 mN/m) and perfluorohexane (PFH, boiling point ∼56°C, surface tension ∼11.9 mN/m) nanodroplets. First, the effects of droplet composition...Continue Reading

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Citations

Oct 5, 2016·Molecular Pharmaceutics·Omer AydinMohamed E H ElSayed
Dec 21, 2016·Physics in Medicine and Biology·Eli VlaisavljevichZhen Xu
Jan 10, 2019·Physics in Medicine and Biology·Catherine PaverdConstantin Coussios
Aug 9, 2019·BioMed Research International·Ksenia LoskutovaMorteza Ghorbani
Dec 15, 2020·Ultrasound in Medicine & Biology·Connor EdsallEli Vlaisavljevich
Jun 1, 2021·Veterinary and Comparative Oncology·Max LatifiJoanne Tuohy
Oct 28, 2021·Physics in Medicine and Biology·Connor EdsallEli Vlaisavljevich

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