Abstract
Extinction following positively reinforced operant conditioning reduces response frequency, at least in part through the aversive or frustrative effects of non-reinforcement. According to J.A. Gray's theory, non-reinforcement activates the behavioural inhibition system which in turn causes anxiety. As predicted, anxiolytic drugs including benzodiazepines affect the operant extinction process. Recent studies have shown that reducing GABA-mediated neurotransmission retards extinction of aversive conditioning. We have shown in a series of studies that anxiolytic compounds that potentiate GABA facilitate extinction of positively reinforced fixed-ratio operant behaviour in C57B1/6 male mice. This effect does not occur in the early stages of extinction, nor is it dependent on cumulative effects of the compound administered. Potentiation of GABA at later stages has the effect of increasing sensitivity to the extinction contingency and facilitates the inhibition of the behaviour that is no longer required. The GABAergic hypnotic, zolpidem, has the same selective effects on operant extinction in this procedure. The effects of zolpidem are not due to sedative action. There is evidence across our series of experiments that different GABA-...Continue Reading
References
Feb 1, 1979·The Quarterly Journal of Experimental Psychology·J FeldonN McNaughton
Jan 1, 1990·Pharmacology & Therapeutics·C F Flaherty
Sep 1, 1969·Journal of Comparative and Physiological Psychology·J A Gray
Nov 1, 1984·The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology·N McNaughton
Jan 1, 1981·Psychopharmacology·J Feldon, J A Gray
Jan 1, 1997·Journal of Neural Transmission·M NazarA Płaźnik
Dec 23, 1998·Psychopharmacology·J A Harris, R F Westbrook
May 20, 1999·Journal of Experimental Psychology. Animal Behavior Processes·J A Nevin, R C Grace
Jul 25, 2000·Psychopharmacology·J R StowellM Sarter
Oct 6, 2000·Science·K LöwU Rudolph
Apr 17, 2001·The Behavioral and Brain Sciences·J A Nevin, R C Grace
Jul 3, 2002·Nature Reviews. Neuroscience·Mark G Baxter, Elisabeth A Murray
Aug 2, 2002·Nature·Giovanni MarsicanoBeat Lutz
Nov 21, 2002·Neuron·Karyn M Myers, Michael Davis
Mar 26, 2003·The European Journal of Neuroscience·Abraham Zangen, Uri Shalev
May 6, 2003·Behavioural Processes·Peter R. Killeen, Matthew T. Sitomer
Nov 1, 1956·Journal of Experimental Psychology·H M ADELMAN, J L MAATSCH
May 31, 1957·Science·C B FERSTER
Mar 1, 1958·Psychological Bulletin·A AMSEL
Jul 1, 1962·Psychological Review·A AMSEL
Dec 19, 2003·Neuropharmacology·Ciara McCabeJulian C Leslie
Citations
Sep 11, 2008·Psychopharmacology·David ShawJulian C Leslie
Apr 25, 2012·Psychopharmacology·Julian C LeslieDavid Shaw
Jun 26, 2012·Psychopharmacology·Karina A ZaninRoberto Frussa-Filho
Sep 11, 2009·Genes, Brain, and Behavior·M FendtC Hölscher
Mar 17, 2007·The International Journal of Neuroscience·Rodrigo PascualAntoni Valero-Cabré
Mar 20, 2012·Behavioural Processes·Timothy H C CheungFederico Sanabria
Mar 20, 2009·Physiology & Behavior·Ma José GómezCarmen Torres
Aug 12, 2008·Behavioural Brain Research·M A José GómezCarmen Torres
Feb 28, 2007·Physiology & Behavior·A MaldonadoA Fernández-Teruel
Sep 24, 2004·The European Journal of Neuroscience·Benjamin K YeeJoram Feldon
Feb 21, 2006·The European Journal of Neuroscience·Irit AkiravMouna Maroun
Oct 6, 2005·Neuroscience·E Martín-García, M Pallarès
Sep 24, 2013·Behavioural Brain Research·Marta SabariegoCarmen Torres
May 2, 2015·Behavioural Brain Research·Yuya Sakimoto, Shogo Sakata
Feb 19, 2013·Neurobiology of Learning and Memory·Julian C Leslie, Kelly Norwood
Jan 3, 2012·Physiology & Behavior·L CuenyaC Torres
Aug 30, 2005·Issues in Mental Health Nursing·Catherine S Cole, Kathy C Richards
Oct 19, 2019·Behavioural Pharmacology·David ShawJulian C Leslie
Apr 7, 2006·Journal of the Experimental Analysis of Behavior·Julian C LeslieGerard R Dawson