Effects of drugs used in endotoxic shock on oxidative stress and organ damage markers

Free Radical Research
E YazarBunyamin Tras

Abstract

The aim of this study was to determine the effects of enrofloxacin (ENR), flunixin meglumine (FM) and dexamethasone (DEX) on antioxidant status and organ damage markers in experimentally-induced endotoxemia. Rats were divided into three groups. To induce endotoxemia, lipopolysaccharide (LPS) was injected into all groups, including the positive control. The two other groups received the following drugs (simultaneously with LPS): ENR + FM + low-dose DEX and ENR + FM + high-dose DEX. After the treatments, blood samples were collected at 0, 1, 2, 4, 6, 8, 12, 24 and 48 h. Oxidative stress parameters were determined by ELISA, while serum organ damage markers were measured by autoanalyser. LSP increased (p < 0.05) malondialdehyde, 13,14-dihydro-15-keto-prostaglandin F(2 alpha) and nitric oxide, while LPS reduced vitamin C. These changes were especially inhibited (p < 0.05) by ENR + FM + high-dose DEX. LPS increased organ damages markers. Cardiac and hepatic damage was not completely inhibited by any treatment, whereas renal damage was inhibited by two treatments. This study suggested that ENR + FM + high-dose DEX is most effective in the LPS-caused oxidative stress and organ damages.

References

Jun 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Kyaw
Aug 8, 1997·Journal of Toxicology and Environmental Health·P R Mayeux
Jan 1, 1997·Free Radical Biology & Medicine·H F GalleyN R Webster
Sep 30, 1998·Lancet·L A KirschenbaumE C Rackow
Aug 12, 1999·European Journal of Pharmacology·J C StocletA L Kleschyov
Jun 7, 2000·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Basu, M Eriksson
Oct 26, 2002·Free Radical Biology & Medicine·Daniela Salvemini, Salvatore Cuzzocrea
Oct 26, 2002·Free Radical Biology & Medicine·Alberto BoverisAna Navarro
Jan 23, 2003·British Journal of Anaesthesia·J MacdonaldN R Webster
Feb 27, 2003·American Journal of Veterinary Research·Clare E BryantHeidi J Janicke
Mar 24, 2004·Inflammopharmacology·A L ParkeD V Parke
Jun 11, 2004·Reproduction, Nutrition, Development·Barbara JanaAdam J Ziecik
Jul 9, 2004·Annals of Internal Medicine·Peter C MinneciCharles Natanson
Sep 22, 2005·Current Opinion in Critical Care·N Makwana, P B Baines
Dec 20, 2005·Veterinary Research Communications·M ElmasA Karabacak
Sep 15, 2006·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·M ElmasA Er Karabacak
Oct 4, 2006·Current Opinion in Anaesthesiology·J Sevransky, C Natanson
Oct 6, 2006·Current Opinion in Anaesthesiology·Michael Booke, Martin Westphal
Dec 13, 2006·Free Radical Biology & Medicine·Feng WuJohn X Wilson
Jan 27, 2007·Critical Care Medicine·Olivier HuetJacques Duranteau
Feb 27, 2007·Archives of Biochemistry and Biophysics·Anje Cauwels, Peter Brouckaert
Sep 22, 2007·Critical Care Medicine·Hans Konrad Biesalski, Gerard Patrick McGregor
Sep 22, 2007·Critical Care Medicine·Mette M Berger, René L Chioléro

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Citations

Mar 25, 2014·Free Radical Biology & Medicine·Anand R NairJoseph Francis
Aug 8, 2018·Canadian Journal of Physiology and Pharmacology·Natalia KurhalukPawel J Winklewski
May 8, 2018·Experimental Animals·Burak DikEmre Bahcivan
May 8, 2020·Molecular Medicine Reports·Chunyan WangZhongjun Zhang

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