Abstract
This experimental setting was undertaken to elucidate and confirm the role of inflammatory and oxidant-antioxidant mechanisms on blunt injury induced moderate pulmonary contusion (PC). We intended to determine the effects of dexamethasone (DXM), N-acetylcysteine (NAC) and aprotinin (APR) in terms of their ability to diminish the consequences of acute lung injury due to PC. Rats were allocated to five subgroups. Except for the control, all subgroups had a moderate pulmonary contusion. Following 45 min of observation, animals in groups I and II received intraperitoneal saline, group III 10 mg/kg DXM, group IV 500 mg/kg NAC and group V 30,000 kIU/ml APR. After the procedure, 6 h after contusion, blood gas analysis, lung tissue nitric oxide (NO) and malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activity, bronchoalveolar lavage (BAL) fluid and histopathological examination were performed. All PaO(2) values decreased significantly in contused rats as compared with the control group (p<0.05). DXM, NAC and APR resulted in a slight increase in PaO(2) values compared with group II (p<0.05). Lung tissue levels of MDA and NO were higher in the contusion group than in the control (p<0.05). DXM, NAC and APR all ...Continue Reading
References
Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Feb 1, 1977·British Journal of Haematology·E BeutlerW N Valentine
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·I Fridovich
Dec 1, 1994·American Journal of Surgery·D R KollmorgenR G Barton
Aug 30, 2000·The Journal of Trauma·R A MaxwellK G Proctor
Aug 30, 2000·Cardiovascular Research·S CuzzocreaA P Caputi
Nov 22, 2000·The Journal of Trauma·K A DavisK G Proctor
Dec 29, 2000·Shock·R A MaxwellK G Proctor
Aug 9, 2001·The Journal of Trauma·P R MillerT C Fabian
Aug 9, 2001·The Journal of Trauma·W J DesselleK G Proctor
Apr 23, 2003·The Journal of Trauma·Nai-dong WangElizabeth H Hammond
Jun 6, 2003·Shock·Markus W KnöferlFlorian Gebhard
Jul 12, 2003·The Journal of Trauma·Michael E KellyKenneth G Proctor
Oct 13, 2004·Pulmonary Pharmacology & Therapeutics·Oguz KokselUgur Oral
May 25, 2005·Injury·Marius Keel, Otmar Trentz
Jun 9, 2005·Critical Care Medicine·Mario PerlMarkus W Knöferl
Jul 27, 2005·Shock·Krishnan RaghavendranPaul R Knight
Oct 11, 2005·Critical Care Medicine·Wolfgang StrohmaierHeinz Redl
Oct 26, 2005·Anesthesia and Analgesia·Krishnan RaghavendranPaul R Knight
Jul 13, 2006·The Journal of Trauma·J Jason HothR Mark Payne
Oct 5, 2006·Current Opinion in Anaesthesiology·Yoram KleinKenneth G Proctor
Citations
Sep 27, 2012·Biological Trace Element Research·Mehmet SırmalıNamık Delibas
Mar 12, 2010·Shock·Susan M SharpeEdwin A Deitch
Sep 22, 2010·Shock·Xiaofa QinEdwin A Deitch
Feb 10, 2011·Journal of Cardiothoracic Surgery·Sami KarapolatAyhan Saritas
Sep 28, 2012·Journal of Cardiothoracic Surgery·Mertol GokceBurak Bahadir
Jun 21, 2013·American Journal of Therapeutics·Shaohua WangJie Zhang
Mar 29, 2014·The Journal of Surgical Research·Minas BaltatzisAthanasios Sakantamis
Jan 21, 2014·Journal of Molecular Histology·Yeter Topcu-TarladacalisirFatma Nesrin Turan
Dec 3, 2011·Injury·Burcin CelikSuleyman Caner Karahan
Oct 8, 2011·Burns : Journal of the International Society for Burn Injuries·C CsontosJ Lantos
Dec 7, 2010·Burns : Journal of the International Society for Burn Injuries·C CsontosJ Lantos
Feb 9, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ender BüyükgüzelKemal Büyükgüzel
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Walter Lemmo
Jul 15, 2015·Oxidative Medicine and Cellular Longevity·Renata Salatti Ferrari, Cristiano Feijó Andrade
Aug 29, 2013·TheScientificWorldJournal·Umit Nusret BasaranMehmet Pul
Aug 28, 2016·The Journal of Surgical Research·Serife OzdincOkan Solak
Jul 31, 2016·Inflammation·Ahmet KozanMehmet Acikgoz
Dec 8, 2016·Shock·Annette PalmerUlrike Niesler
Dec 22, 2017·Photomedicine and Laser Surgery·Ingvill Fjell NaterstadRodrigo Alvaro Brandão Lopes-Martins
Apr 2, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·N BıçakçıZ Fidanol Erboğa
Aug 18, 2020·Drug Design, Development and Therapy·Seyfi KartalMustafa Kavutçu
Nov 22, 2020·International Immunopharmacology·Yongjie WangDeqing Sun
Oct 3, 2021·Inflammation·Hui LinLiqun Shan