Effects of early amino acid administration on leucine and glucose kinetics in premature infants

Pediatric Research
C H P van den AkkerJ B van Goudoever

Abstract

We previously showed that, in prematurely born infants, an anabolic state without metabolic acidosis can be achieved upon intravenous amino acid (AA) administration in the immediate postnatal phase, despite a low energy intake. We hypothesized that the anabolic state resulted from an increased protein synthesis and not a decreased proteolysis. Furthermore, we hypothesized that the energy needed for the higher protein synthesis rate would be derived from an increased glucose oxidation. To test our hypotheses, 32 ventilated premature infants (<1500 g) received intravenously either solely glucose or glucose and 2.4 g AA/kg/d immediately postnatally. On postnatal d 2, each group received primed continuous infusions of either [1-13C]leucine or [U-13C6]glucose. 13CO2 enrichments in expiratory air and plasma [1-13C]alpha-KICA (as an intracellular leucine precursor) and [U-13C6]glucose enrichments were measured by mass spectrometry techniques. The AA administration resulted in an increased incorporation of leucine into body protein and a higher leucine oxidation rate, whereas leucine release from proteolysis was not affected. Glucose oxidation rate did not increase upon AA administration. In conclusion, the anabolic state resulting fro...Continue Reading

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Citations

Dec 5, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Satish C Kalhan, John M Edmison
Mar 11, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Chris H P van den AkkerJohannes B van Goudoever
Jun 23, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·H A de Boo, J E Harding
Apr 9, 2008·Annual Review of Nutrition·Satish C Kalhan, Dennis M Bier
Jul 1, 2011·Annals of Nutrition & Metabolism·Willemijn E CorpeleijnJohannes B van Goudoever
Oct 4, 2012·Critical Care : the Official Journal of the Critical Care Forum·Carlijn T I de BetueKoen F M Joosten
May 30, 2008·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Onno K HelderJohannes B van Goudoever
Nov 6, 2007·Early Human Development·Nicholas D Embleton
Dec 5, 2006·Seminars in Fetal & Neonatal Medicine·F W J te BraakeJ B van Goudoever
May 11, 2013·The Journal of Pediatrics·Hester VlaardingerbroekJohannes B van Goudoever
May 27, 2014·Molecular Genetics and Metabolism·Avihu Boneh
Jan 28, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Hester VlaardingerbroekChris H P van den Akker
Oct 28, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Shujiro FujitaYoshihiro Ishikawa
Feb 4, 2016·Revista da Associação Médica Brasileira·Adriana Martins de LimaBenjamin Israel Kopelman
Apr 21, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Ajit MahaveerColin Morgan
Jul 25, 2013·The Cochrane Database of Systematic Reviews·Amit Trivedi, John K H Sinn
Mar 6, 2018·The Cochrane Database of Systematic Reviews·David A OsbornSrinivas Bolisetty
Jun 28, 2011·Journal of Pediatric Gastroenterology and Nutrition·Thibault Senterre, Jacques Rigo
Jan 6, 2007·Journal of Pediatric Gastroenterology and Nutrition·Luca MaggioCostantino Romagnoli
Oct 21, 2006·The Cochrane Database of Systematic Reviews·L M Soghier, L P Brion
Jan 20, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jan Erik H BuntJohannes B van Goudoever
Jan 10, 2012·Journal of Pediatric Gastroenterology and Nutrition·Cynthia L BlancoRajam Ramamurthy
Sep 5, 2014·Journal of Pediatric Gastroenterology and Nutrition·Chris H P van den AkkerJohannes B van Goudoever
Oct 3, 2020·The Cochrane Database of Systematic Reviews·Shoichiro AmariRintaro Mori
Oct 9, 2007·The American Journal of Clinical Nutrition·Chris H P van den AkkerJohannes B van Goudoever
Aug 6, 2013·Journal of Diabetes Science and Technology·Jennifer L DicksonJ Geoffrey Chase
Oct 21, 2020·The Journal of Clinical Endocrinology and Metabolism·Froukje VanweertEsther Phielix
Apr 3, 2008·Pediatrics·C H P van den AkkerJ B van Goudoever

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