Abstract
International and Japanese guidelines classify childhood asthma as mild, moderate, or severe, and recommend treatment with "as needed" bronchodilators, inhaled sodium cromoglycate, and inhaled corticosteroids, respectively. Alternatively, some investigators proposed inhaled corticosteroids as first-line therapy to prevent airway inflammatory obstruction. This article describes a clinical study assessing the effect of early intervention with inhaled sodium cromoglycate in childhood asthma. This was a retrospective study of 189 asthmatic children treated with inhaled sodium cromoglycate for five years and whose age of onset of asthma was six year of age or younger. An end-of-study questionnaire completed the examination. Children administered oral or inhaled corticosteroids simultaneously with sodium cromoglycate, were excluded. Asthma scores as defined by the Japanese Pediatric Allergic Committee, were reduced continuously during the five years after the start of sodium cromoglycate treatment. The frequency of emergency department visits and hospitalizations also decreased. Significant between-period intervention differences showed improvement of clinical outcomes for children with severe asthma during the five years of sodium c...Continue Reading
References
Feb 1, 1992·Archives of Disease in Childhood
May 1, 1987·The Journal of Allergy and Clinical Immunology·D W Cockcroft, K Y Murdock
Oct 1, 1983·Pediatric Clinics of North America·B A Berman
Nov 1, 1995·Chest·O SelroosH Riska
May 1, 1994·Respiratory Medicine·L Agertoft, S Pedersen
Oct 1, 1993·European Journal of Pediatrics·C A MacKenzieK Crescenzi
Nov 1, 1993·The American Review of Respiratory Disease·H J WaalkensK F Kerrebijn
Jul 1, 1996·Chest·S E OverbeekD S Postma
Dec 1, 1996·The Journal of Allergy and Clinical Immunology·P König, J Shaffer
Feb 23, 1999·Controlled Clinical Trials
Mar 9, 1999·The Journal of Allergy and Clinical Immunology·R S ZeigerS Weiss
Mar 10, 1999·Respiratory Medicine·M HoshinoH Tomioka
Jun 3, 2000·The European Respiratory Journal·K KorhonenK Remes
Jul 19, 2000·Thorax·P G Holt, P D Sly
Oct 12, 2000·The New England Journal of Medicine·UNKNOWN Childhood Asthma Management Program Research GroupRobert Zeiger
Jul 30, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Kenshi FurushoAlan Edwards
Citations
Apr 21, 2010·Expert Review of Clinical Immunology·Shigemi Yoshihara
Feb 17, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·Chenxia HaoYouqiu He
Aug 21, 2013·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Shigemi Yoshihara
May 10, 2007·Current Opinion in Allergy and Clinical Immunology