Effects of early postnatal hyperglycaemia on renal cortex maturity, endothelial nitric oxide synthase expression and nephron deficit in mice.

International Journal of Experimental Pathology
Ana Rosa CunhaCarlos Alberto Mandarim-de-Lacerda

Abstract

The influence of hyperglycaemia on nephrogenesis on Swiss mice pups treated with streptozotocin (STZ) (40 mg/kg, i.p.) was studied after birth, at 7 and 21 days. Kidneys were prepared for light microscopy, immunohistochemistry and stereology. In 7-day-old pups, both immature and mature glomeruli were evaluated separately. Proliferating cell nuclear antigen (PCNA) and endothelial nitric oxide synthase (eNOS) immunostaining were performed and quantified. At age 7 days, the immature-to-mature glomeruli ratio (IMGR) was significantly higher in the STZ group than in the control group. There was no difference in the number of glomeruli between the STZ and control groups; however, the number of glomeruli increased by more than 20% in the control group until 21 days of age, but not in the STZ group. STZ pups showed numerous PCNA-positive nuclei mainly in tubular cells, but not control pups. At 21 days, eNOS expression in the outer layer of glomerular endothelial nuclei was strong in control pups, but weaker in STZ pups. Treatment with STZ during the early neonatal period disturbs the normal nephrogenesis occurring at this stage of the rodent's life and causes retardation in renal cortical maturity, as indicated by the increase in both ...Continue Reading

References

Jun 1, 1986·Obstetrical & Gynecological Survey·E A Reece, J C Hobbins
Oct 1, 1988·American Journal of Hypertension·B M BrennerS Anderson
Sep 1, 1996·Kidney International·T GilbertC Merlet-Bénichou
Dec 1, 1996·The Journal of Clinical Investigation·Y S KanwarE I Wallner
Jan 1, 1997·British Medical Bulletin·D J Barker
Aug 27, 1999·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·T NadasdyF G Silva
Jul 6, 2000·British Journal of Pharmacology·A S De VrieseP M Vanhoutte
Sep 10, 2002·American Journal of Physiology. Renal Physiology·Zubaida SaifudeenSamir S El-Dahr
Nov 8, 2003·Anais Da Academia Brasileira De Ciências·Carlos A Mandarim-de-Lacerda
Feb 3, 2004·Journal of Cellular and Molecular Medicine·J R AlmeidaC A Mandarim-De-Lacerda
Sep 18, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Cristina CebriánDoris A Herzlinger
Dec 2, 2004·American Journal of Physiology. Renal Physiology·Ki-Hwan HanJin Kim
Mar 5, 2005·American Journal of Obstetrics and Gynecology·Jorge R Almeida, Carlos A Mandarim-de-Lacerda
May 6, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yashpal S KanwarFarhad R Danesh
Jun 7, 2005·Journal of the American Society of Nephrology : JASN·Marie-Luise GrossEberhard Ritz
Jun 18, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lori L WoodsRuth Rasch
Jul 7, 2005·Physiological Genomics·G ChallenS M Grimmond
Jul 23, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·M Z MughalJ E Adams
Jan 18, 2006·Hypertension·Kambiz Zandi-NejadBarry M Brenner
Aug 8, 2006·Life Sciences·Karla Maria Pereira PiresCarlos Alberto Mandarim-de-Lacerda
Sep 16, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chantal C HoppeJohn F Bertram
Nov 25, 2006·Nature Clinical Practice. Nephrology·David J P BarkerMark A Hanson

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Citations

Aug 14, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Erin M DavisPeter Langlois
Jun 20, 2014·Lab Animal·Lorena ArizaPedro José Otaegui

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