Effects of edifenphos and glyphosate on the immune response and protein biosynthesis of bolti fish (Tilapia nilotica)

Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
K S el-GendyA H el-Sebae

Abstract

The effects of 1/1000 field recommended concentration of the organophosphorus compounds; edifenphos and glyphosate on the immune response and protein contents were investigated after different time intervals. The cell mediated immune response assessed by proliferative response of splenocytes to mitogens; phytohemagglutinin (PHA) and concanavalin A (Con A) for T cell and lipopolysaccharide (LPS) for B cell decreased significantly in tems of the level of stimulation index in the treated fish and reached maximal depression after 4 weeks. Humoral immunity assessed as splenic antibody plaque forming cells (PFC) measured after 5 days in vitro immunization to sheep erythrocytes (SRBC's) were suppressed in a concentration dependent pattern by the two compounds. The estimated ED50 for the PFC/10(6) cells of edifenphos and glyphosate were 1.48 x 10(-2) uM and 1.65 x 10(-2) uM respectively. The data also showed that serum antibody titres in the treated fish were decreased in a time dependent manner. The total protein content of serum treated with the two pesticides was decreased after different time periods compared with control. The blood serum of treated and untreated Tilapia nilotica were analyzed electrophoretically for protein compon...Continue Reading

Citations

Apr 15, 2007·Pakistan Journal of Biological Sciences : PJBS·Cecil A MattaAshraf M Abdel-Moneim
Nov 12, 2013·Toxicology and Industrial Health·Nahla Elsayed Omran, Wesam Mohamed Salama
Feb 29, 2000·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·N M Aly, K S el-Gendy
Oct 9, 2008·Ecological Applications : a Publication of the Ecological Society of America·Jason R RohrPeter J Hudson
Sep 9, 2020·Journal of Immunotoxicology·Cindy Peillex, Martin Pelletier
Jan 26, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Prem RajakSumedha Roy
May 18, 2021·Journal of Biomolecular Structure & Dynamics·Ajaz AhmadMasood Ahmad

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