PMID: 9630646Jun 19, 1998Paper

Effects of EGb 761 on nitric oxide and oxygen free radicals, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo

Biochimica Et Biophysica Acta
J ShenW Xin

Abstract

The cardioprotective effects of EGb 761 on the release of nitric oxide (NO), the concentration of serum thiobarbituric acid reaction substance (TBARS), the activity of creatine kinase (CK) and the incidence of ventricular arrhythmias were investigated in myocardial ischemia-reperfusion injury in vivo. Using sodium nitrite (NaNO2) as standard source of nitric oxide (NO), we compared the correlation coefficients of the three measuring methods used currently in the determination of NOFe2+(DETC)2 complex with that of the measuring method suggested in this study. The result showed that measuring the whole height of three splitting signals is the best linear correlation to the concentration of NO comparing with other methods in this system. Using this method, we observed the effects of EGb 761 on NOFe2+(DETC)2 complex in myocardial ischemia-reperfusion injury in vivo. The hearts of the Wistar rats were subjected to 30 min of ischemia and 10 min of reperfusion in vivo. Different doses of EGb 761 (25, 50, 100, 200 mg/kg i.p.), superoxide dismutase (SOD, 10(4) U/kg), l-arginine (50 mg/kg i.p.) and nitric oxide synthase (NOS) inhibitor NG-nitro-l-arginine (NNA, 50 mg/kg i.p.) were administered to the ischemia-reperfusion rats. EGb 761 un...Continue Reading

Citations

Mar 20, 2010·Journal of Bioenergetics and Biomembranes·Giedre BaliutyteAdolfas Toleikis
Jan 31, 2006·Molecular and Cellular Biochemistry·Göksel SenerNursal Gedik
Dec 17, 2003·Journal of Magnetic Resonance·J Y RenF H Y Chan
May 18, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Göksel SenerAbdullah Sakarcan
Oct 9, 2002·Clinical and Experimental Pharmacology & Physiology·Yasuto SasakiJunichiro Yamamoto
May 26, 2010·Journal of Brachial Plexus and Peripheral Nerve Injury·Xiao ChengLi-Hua Zhou
May 15, 2007·Brain Research·L PiehlJ J López-Costa
Oct 23, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y QianY Q Sun
Aug 15, 2014·Experimental Neurology·Lais Takata WalterAlexandre Hiroaki Kihara
Feb 3, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Göksel SenerGülden Z Omurtag
Mar 24, 2004·Journal of Pharmacological Sciences·Zhong-Fang LaiKatsuhide Nishi
Feb 10, 2004·Cardiology in Review·Mina K Chung
Oct 14, 2005·World Journal of Gastroenterology : WJG·Göksel SenerYnci Alican
Nov 10, 2006·Phytotherapy Research : PTR·Ayfer TozanGöksel Sener
Nov 10, 2005·The Journal of Burn Care & Rehabilitation·Abdullah SakarcanGöksel Sener
Jun 2, 2020·Frontiers in Pharmacology·Arpad Tosaki
May 7, 2005·Canadian Journal of Physiology and Pharmacology·Yaw L SiowKarmin O
Jan 15, 2000·The Journal of Biological Chemistry·K TsuchiyaR P Mason

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.