Effects of Egg Consumption and Choline Supplementation on Plasma Choline and Trimethylamine-N-Oxide in a Young Population

Journal of the American College of Nutrition
Bruno S LemosMaria Luz Fernandez

Abstract

Plasma trimethylamine-N-oxide (TMAO) concentrations have been associated with cardiovascular disease risk. Eggs are a rich source of choline, which is a precursor of TMAO. The effects of egg intake versus daily choline supplementation were evaluated on plasma choline and TMAO in a young, healthy population. Thirty participants (14 males, 16 females; 25.6 ± 2.3 years; body mass index = 24.3 ± 2.9 kg/m2) were enrolled in this 13-week crossover intervention. After a 2-week washout, participants were randomized to consume either 3 eggs/d or a choline bitartrate supplement (∼ 400 mg choline total in eggs or supplement) for 4 weeks. Following a 3-week washout, participants were switched to the alternate treatment. Dietary records were measured at the end of each period. Plasma TMAO and choline were measured at baseline and at the end of each dietary intervention. Gene expression of scavenger receptors associated with plasma TMAO were quantified at the end of each intervention. Compared to the choline supplement, intake of total fat, cholesterol, selenium, and vitamin E were higher (p < 0.05), whereas carbohydrate intake was lower (p < 0.001) with consumption of 3 eggs/d. Fasting plasma choline increased 20% (p = 0.023) with egg intak...Continue Reading

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Citations

May 13, 2020·Nutrients·Christopher PapandreouAouatef Bellamine
Oct 22, 2020·BioMed Research International·Xin WangYumei Dong
Feb 18, 2021·Current Atherosclerosis Reports·Minu S Thomas, Maria Luz Fernandez
Mar 12, 2021·The Journal of Nutritional Biochemistry·Paulina Aldana-HernándezRené L Jacobs
May 1, 2021·Nutrients·Mauro LombardoAntonino De Lorenzo
May 2, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Luc DjousséJoAnn E Manson
Aug 17, 2021·Journal of Agricultural and Food Chemistry·Ying Qi GohYulan Wang
Aug 24, 2021·Frontiers in Psychiatry·Mariana RomanenkoAlexander Vaiserman

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